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Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats
Ge, Yanjun; Feng, Hailan; Wang, Lei1
关键词Guided bone regeneration resorbable membrane bone substitute critical size defects Diplen-Gam membrane
刊名JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
2011
DOI10.1163/092050610X540477
22期:18页:2417-2429
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]Engineering ; Materials Science ; Polymer Science
关键词[WOS]BONE REGENERATION ; MODEL ; AUGMENTATION ; REPAIR
英文摘要

Diplen-Gam (DG) is a novel absorbable guided bone regeneration (GBR) membrane. This study was designed to evaluate the capacity of bone repair of DG compared with that of Bio-Gide (BG). Critical size defects were created in both sides of the calcarium of 36 Sprague-Dawley rats. Defects were assigned to six groups and each group was subjected to one of the following treatments: (A1) unfilled defects, (A2) Bio-Oss (BO) grafts, (B1) DG membrane, (B2) BG membrane, (C1) DG membrane + BO grafts and (C2) BG membrane + BO grafts. The animals were killed at 2, 4, 8 and 12 weeks after the operation. The defects and surrounding tissues were examined by gross observation and X-ray examination. The paraffin sections were subjected to HE (hematoxylin and eosin) staining and IHC (immunohistochemistry) for bone morphogenetic protein-2 (BMP-2). The X-rays showed that, at 12 weeks, the DG and BG group exhibited more new bone formation than CSD blank group did; the BG group exhibited more new bone formation than the DG group did (t = 5.240, P = 0.035), the BG + BO group showed no significant differences in bone formation compared with the DG + BO group (t = 1.246, P = 0.339). By IHC staining, BMP-2-positive results could be seen inside the DG membrane, on the surface of the new bone, and inside the new bone. It can be suggested that BG membrane achieved better effects in guided bone regeneration compared with DG membrane. No significant differences were found between the two membranes in their bone healing ability when they are used with BO. Therefore, DG membrane shows clinical effectiveness, but should be used in combination with bone substitute. (C) Koninklijke Brill NV, Leiden, 2011

语种英语
WOS记录号WOS:000297423800003
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66187
专题北京大学口腔医学院_口腔修复科
作者单位1.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
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Ge, Yanjun,Feng, Hailan,Wang, Lei. Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2011,22(18):2417-2429.
APA Ge, Yanjun,Feng, Hailan,&Wang, Lei.(2011).Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,22(18),2417-2429.
MLA Ge, Yanjun,et al."Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 22.18(2011):2417-2429.
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