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学科主题: 口腔医学
题名:
Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats
作者: Ge, Yanjun; Feng, Hailan; Wang, Lei1
关键词: Guided bone regeneration ; resorbable membrane ; bone substitute ; critical size defects ; Diplen-Gam membrane
刊名: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
发表日期: 2011
DOI: 10.1163/092050610X540477
卷: 22, 期:18, 页:2417-2429
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]: Engineering ; Materials Science ; Polymer Science
关键词[WOS]: BONE REGENERATION ; MODEL ; AUGMENTATION ; REPAIR
英文摘要:

Diplen-Gam (DG) is a novel absorbable guided bone regeneration (GBR) membrane. This study was designed to evaluate the capacity of bone repair of DG compared with that of Bio-Gide (BG). Critical size defects were created in both sides of the calcarium of 36 Sprague-Dawley rats. Defects were assigned to six groups and each group was subjected to one of the following treatments: (A1) unfilled defects, (A2) Bio-Oss (BO) grafts, (B1) DG membrane, (B2) BG membrane, (C1) DG membrane + BO grafts and (C2) BG membrane + BO grafts. The animals were killed at 2, 4, 8 and 12 weeks after the operation. The defects and surrounding tissues were examined by gross observation and X-ray examination. The paraffin sections were subjected to HE (hematoxylin and eosin) staining and IHC (immunohistochemistry) for bone morphogenetic protein-2 (BMP-2). The X-rays showed that, at 12 weeks, the DG and BG group exhibited more new bone formation than CSD blank group did; the BG group exhibited more new bone formation than the DG group did (t = 5.240, P = 0.035), the BG + BO group showed no significant differences in bone formation compared with the DG + BO group (t = 1.246, P = 0.339). By IHC staining, BMP-2-positive results could be seen inside the DG membrane, on the surface of the new bone, and inside the new bone. It can be suggested that BG membrane achieved better effects in guided bone regeneration compared with DG membrane. No significant differences were found between the two membranes in their bone healing ability when they are used with BO. Therefore, DG membrane shows clinical effectiveness, but should be used in combination with bone substitute. (C) Koninklijke Brill NV, Leiden, 2011

语种: 英语
WOS记录号: WOS:000297423800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66187
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China

Recommended Citation:
Ge, Yanjun,Feng, Hailan,Wang, Lei. Application of a Novel Resorbable Membrane in the Treatment of Calvarial Defects in Rats[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2011,22(18):2417-2429.
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