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Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment
Liu, Ying1,2; Han, Mei1; Liu, Xingdang2; Deng, Yanping3; Li, Yu4; Yuan, Jie2; Lv, Rongbin2; Wang, Yuankai2; Zhang, Guangming2; Gao, Jinlong1
关键词Dopamine transporter Heroin dependence Single-photon emission computed tomography Jitai tablets
刊名PSYCHOPHARMACOLOGY
2013-11-01
DOI10.1007/s00213-013-3148-z
230期:2页:235-244
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; TANDEM MASS-SPECTROMETRY ; FREELY MOVING RATS ; METHAMPHETAMINE ABUSERS ; PARKINSONS-DISEASE ; NUCLEUS-ACCUMBENS ; DRUG-ADDICTION ; USERS ; DEPRESSION ; SPECT
英文摘要

Previous imaging studies have indicated that the levels of the dopamine transporter (DAT) are reduced in the brains of heroin users. However, whether these changes can be reversed by abstinence and/or treatment remains unclear.

This study aims to investigate DAT availability in heroin users and changes in DAT availability after abstinence and treatment with the Jitai tablets, a traditional Chinese medicinal product that is approved for the treatment of opioid addiction.

Single-photon emission computed tomography (SPECT) with [Tc-99m] TRODAT-1 was performed on heroin-dependent patients (n = 64) and healthy controls (n = 15). The patients were randomly assigned to treatment with either placebo or the Jitai. All patients underwent SPECT imaging both at baseline and after 6 months of treatment. DAT availability was assessed in the caudate and putamen. Depression and anxiety were evaluated at baseline.

DAT availability remained at low levels during a 6-month period in the placebo-treated group but was increased (14-17 %) in the Jitai-treated group. The ratio of DAT availability at month 6 to that at baseline in the Jitai-treated group was significantly higher than that in the placebo-treated group in both the bilateral caudate and putamen. DAT uptake in the striatum was significantly correlated with daily heroin dose, years of heroin use, and depression.

These findings suggest that chronic heroin use induces long-lasting striatal DAT reductions. DAT availability remained unchanged during a 6-month period of abstinence. Treatment with Jitai appears to be effective at increasing striatal DAT availability.

语种英语
WOS记录号WOS:000326117800006
项目编号2008BA149B04 ; 2008BA149B01 ; 81173139 ; 21233003
资助机构National Key Technology R&amp ; D Program of China ; China National Science Foundation ; Major Research Plan of NSFC
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66200
专题中国药物依赖性研究所
作者单位1.Drug Rehabil Ctr, Shanghai, Peoples R China
2.Beijing Normal Univ, Key Lab Radiopharmaceut, Coll Chem, Beijing 100875, Peoples R China
3.Fudan Univ, Dept Nucl Med, Huashan Hosp, Shanghai 200433, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Ying,Han, Mei,Liu, Xingdang,et al. Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment[J]. PSYCHOPHARMACOLOGY,2013,230(2):235-244.
APA Liu, Ying.,Han, Mei.,Liu, Xingdang.,Deng, Yanping.,Li, Yu.,...&Gao, Jinlong.(2013).Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment.PSYCHOPHARMACOLOGY,230(2),235-244.
MLA Liu, Ying,et al."Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment".PSYCHOPHARMACOLOGY 230.2(2013):235-244.
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