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学科主题: 口腔医学
题名:
Diabetes aggravates periodontitis by limiting repair through enhanced inflammation
作者: Pacios, Sandra1,3; Kang, Jun1,4,5; Galicia, Johnah1; Gluck, Kenneth6; Patel, Hemal1; Ovaydi-Mandel, Amy6; Petrov, Sophia6; Alawi, Faizan2; Graves, Dana T.1
关键词: bone formation ; cytokine ; growth factor ; inhibitor
刊名: FASEB JOURNAL
发表日期: 2012-04-01
DOI: 10.1096/fj.11-196279
卷: 26, 期:4, 页:1423-1430
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; BONE LOSS ; FACTOR-ALPHA ; TISSUE DESTRUCTION ; IN-VIVO ; INHIBITION ; RESORPTION ; MICE ; ANTAGONISTS ; INFECTION
英文摘要:

Periodontitis is the most common lytic bone disease and one of the first clinical manifestations of diabetes. Diabetes increases the risk of periodontitis. The aim of the present study was to examine mechanisms by which diabetes aggravates periodontitis. Ligature-induced periodontitis was examined in Goto-Kakizaki rats with type 2 diabetes. A tumor necrosis factor (TNF)-specific-inhibitor, pegsunercept, was applied to diabetic rats after the onset of periodontal disease. Interferon-gamma (IFN-gamma), TNF-alpha, interleukin-1 beta (IL-1 beta), fibroblast growth factor-2 (FGF-2), transforming growth factor beta-1 (TGF beta-1), bone morphogenetic protein-2 (BMP-2), and BMP-6 were measured by real-time RT-PCR, and histological sections were examined for leukocyte infiltration and several parameters related to bone resorption and formation. Inflammation was prolonged in diabetic rats and was reversed by the TNF inhibitor, which reduced cytokine mRNA levels, leukocyte infiltration, and osteoclasts. In contrast, new bone and osteoid formation and osteoblast numbers were increased significantly vs. untreated diabetic animals. TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone-lining cells, and increased mRNA levels of FGF-2, TGF beta-1, BMP-2, and BMP-6. Thus, diabetes prolongs inflammation and osteoclastogenesis in periodontitis and through TNF limits the normal reparative process by negatively modulating factors that regulate bone.-Pacios, S., Kang, J., Galicia, J., Gluck, K., Patel, H., Ovaydi-Mandel, A., Petrov, S., Alawi, F., Graves, D. T. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J. 26, 1423-1430 (2012). www.fasebj.org

语种: 英语
所属项目编号: DE018307 ; DE0DE17732
项目资助者: U.S. National Institute of Dental and Craniofacial Research
WOS记录号: WOS:000302359700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66205
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Univ Penn, Dept Periodont, Sch Dent Med, Philadelphia, PA 19104 USA
2.Univ Penn, Dept Pathol, Sch Dent Med, Philadelphia, PA 19104 USA
3.Univ Int Catalunya, Dept Periodont, Sch Dent Med, Sant Cugat Del Valles, Spain
4.Peking Univ, Dept Periodont, Sch Stomatol, Beijing 100871, Peoples R China
5.Peking Univ, Dept Periodont, Hosp Stomatol, Beijing 100871, Peoples R China
6.Univ Med & Dent New Jersey, New Jersey Dent Sch, Dept Periodont, Newark, NJ 07103 USA

Recommended Citation:
Pacios, Sandra,Kang, Jun,Galicia, Johnah,et al. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation[J]. FASEB JOURNAL,2012,26(4):1423-1430.
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