IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Diabetes aggravates periodontitis by limiting repair through enhanced inflammation
Pacios, Sandra1,3; Kang, Jun1,4,5; Galicia, Johnah1; Gluck, Kenneth6; Patel, Hemal1; Ovaydi-Mandel, Amy6; Petrov, Sophia6; Alawi, Faizan2; Graves, Dana T.1
关键词bone formation cytokine growth factor inhibitor
刊名FASEB JOURNAL
2012-04-01
DOI10.1096/fj.11-196279
26期:4页:1423-1430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; BONE LOSS ; FACTOR-ALPHA ; TISSUE DESTRUCTION ; IN-VIVO ; INHIBITION ; RESORPTION ; MICE ; ANTAGONISTS ; INFECTION
英文摘要

Periodontitis is the most common lytic bone disease and one of the first clinical manifestations of diabetes. Diabetes increases the risk of periodontitis. The aim of the present study was to examine mechanisms by which diabetes aggravates periodontitis. Ligature-induced periodontitis was examined in Goto-Kakizaki rats with type 2 diabetes. A tumor necrosis factor (TNF)-specific-inhibitor, pegsunercept, was applied to diabetic rats after the onset of periodontal disease. Interferon-gamma (IFN-gamma), TNF-alpha, interleukin-1 beta (IL-1 beta), fibroblast growth factor-2 (FGF-2), transforming growth factor beta-1 (TGF beta-1), bone morphogenetic protein-2 (BMP-2), and BMP-6 were measured by real-time RT-PCR, and histological sections were examined for leukocyte infiltration and several parameters related to bone resorption and formation. Inflammation was prolonged in diabetic rats and was reversed by the TNF inhibitor, which reduced cytokine mRNA levels, leukocyte infiltration, and osteoclasts. In contrast, new bone and osteoid formation and osteoblast numbers were increased significantly vs. untreated diabetic animals. TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone-lining cells, and increased mRNA levels of FGF-2, TGF beta-1, BMP-2, and BMP-6. Thus, diabetes prolongs inflammation and osteoclastogenesis in periodontitis and through TNF limits the normal reparative process by negatively modulating factors that regulate bone.-Pacios, S., Kang, J., Galicia, J., Gluck, K., Patel, H., Ovaydi-Mandel, A., Petrov, S., Alawi, F., Graves, D. T. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J. 26, 1423-1430 (2012). www.fasebj.org

语种英语
WOS记录号WOS:000302359700005
Citation statistics
Cited Times:58[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66205
Collection北京大学口腔医学院
北京大学口腔医学院_牙周科
作者单位1.Univ Penn, Dept Periodont, Sch Dent Med, Philadelphia, PA 19104 USA
2.Univ Penn, Dept Pathol, Sch Dent Med, Philadelphia, PA 19104 USA
3.Univ Int Catalunya, Dept Periodont, Sch Dent Med, Sant Cugat Del Valles, Spain
4.Peking Univ, Dept Periodont, Sch Stomatol, Beijing 100871, Peoples R China
5.Peking Univ, Dept Periodont, Hosp Stomatol, Beijing 100871, Peoples R China
6.Univ Med & Dent New Jersey, New Jersey Dent Sch, Dept Periodont, Newark, NJ 07103 USA
Recommended Citation
GB/T 7714
Pacios, Sandra,Kang, Jun,Galicia, Johnah,et al. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation[J]. FASEB JOURNAL,2012,26(4):1423-1430.
APA Pacios, Sandra.,Kang, Jun.,Galicia, Johnah.,Gluck, Kenneth.,Patel, Hemal.,...&Graves, Dana T..(2012).Diabetes aggravates periodontitis by limiting repair through enhanced inflammation.FASEB JOURNAL,26(4),1423-1430.
MLA Pacios, Sandra,et al."Diabetes aggravates periodontitis by limiting repair through enhanced inflammation".FASEB JOURNAL 26.4(2012):1423-1430.
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