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学科主题: 临床医学
题名:
Lymph node distribution and pattern of metastases in the mesorectum following total mesorectal excision using the modified fat clearing technique
作者: Yao, Yun-Feng1; Wang, Lin1; Liu, Yi-Qiang2; Li, Ji-You2; Gu, Jin1
刊名: JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2011-12-01
DOI: 10.1136/jclinpath-2011-200190
卷: 64, 期:12, 页:1073-1077
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: RECTAL-CANCER ; COLORECTAL-CANCER ; COLON-CANCER ; SIZE ; CARCINOMA ; NUMBER ; IMPACT ; MICROMETASTASES ; RETRIEVAL ; SPECIMENS
英文摘要:

Aim To define the distribution, size, location and metastasis of lymph nodes (LNs) within the mesorectum from rectal cancer specimens following total mesorectal excision (TME) surgery without neoadjuvant therapy.

Methods Specimens from 60 patients who underwent TME were treated with modified fat clearing solution to retrieve LNs. The mesorectum was divided into right lateral, anterior, posterior and left lateral sides, which were further subdivided into three levels (upper, middle and lower).

Results 1436 LNs were harvested, including 985 small LNs (< 5 mm in size). The number of LNs from the anterior, posterior and bilateral mesorectum was 125 (8.7%), 696 (48.5%) and 615 (42.8%), respectively. In the longitudinal axis, the difference in distribution at the three levels was not significant. 200 LN metastases (mLNs) were detected in 33 patients. 48% (96/200) of these were small LNs. More mLNs, especially small LNs, were shown in the more advanced T stage patients. The mLN metastasis rate was not influenced by tumour level.

Conclusion Small LN detection increased the accuracy of N staging by 20% in this study. The incidence of metastasis was the same among the anterior, bilateral and posterior areas of the mesorectum. An increased incidence of mLN metastasis in small LNs was associated with more advanced T staging. mLN metastasis rates in both middle and low rectal cancer were higher in the distal mesorectum than that in the proximal mesorectum. LN number and density were not consistent with spread of the primary tumour. Distal mLNs were found in 35% of cases of both middle and distal rectal cancer, implying a need for TME in both.

语种: 英语
WOS记录号: WOS:000297263100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66207
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Colorectal Surg,Beijing Canc Hosp & Inst,Sch, Beijing 100871, Peoples R China
2.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China

Recommended Citation:
Yao, Yun-Feng,Wang, Lin,Liu, Yi-Qiang,et al. Lymph node distribution and pattern of metastases in the mesorectum following total mesorectal excision using the modified fat clearing technique[J]. JOURNAL OF CLINICAL PATHOLOGY,2011,64(12):1073-1077.
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