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学科主题: 临床医学
题名:
ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions
作者: Liu, Xiao-Hong1,2,3,4; Yan, Li-Ying1,2,3; Lu, Cui-Ling1,2,3; Li, Rong1,2,3; Zhu, Xiao-Hui1,2,3; Jin, Hong-Yan1,2,3; Zhang, Yan1,2,3; Zhang, Wen-Xin1,2,3; Gao, Su-Hong4; Qiao, Jie1,2,3
关键词: assisted reproductive technology ; ICSI ; male infertility ; outcomes
刊名: REPRODUCTION FERTILITY AND DEVELOPMENT
发表日期: 2014
DOI: 10.1071/RD13092
卷: 26, 期:6, 页:778-786
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Reproductive Biology ; Zoology
研究领域[WOS]: Developmental Biology ; Reproductive Biology ; Zoology
关键词[WOS]: INTRACYTOPLASMIC SPERM INJECTION ; DEPENDENT PROBE AMPLIFICATION ; IN-VITRO FERTILIZATION ; OF-THE-ART ; INFERTILE MEN ; VERTICAL TRANSMISSION ; PRENATAL-DIAGNOSIS ; FOLLOW-UP ; DELETIONS ; CHILDREN
英文摘要:

Y-chromosome microdeletions (YCMs) have been found at a much higher rate in infertile men than fertile controls. Aspecific deletion in the azoospermia factor locus (AZF) at Yq11 is significantly associated with male infertility. Whether assisted reproductive technology (ART) increases the risk of YCM in ART-derived offspring remains unclear. In this study the occurrence of YCM in 199 fathers and their 228 sons (Chinese, Han ethnicity), including 85 offspring conceived by IVF, 73 by intra-cytoplasmic sperm injection (ICSI) and 70 by natural conception, was investigated. Nineteen candidate genes related to YCM were analysed by multiplex ligation-dependent probe amplification. We identified one de novo YCM from 70 naturally-conceived offspring and none from 158 ART-conceived offspring and found no statistical significance between these two groups. There was no statistically-significant difference in the detection rate of the father′s Y-chromosome microdeletion group: IVF 10.7% (8/75), ICSI 3.2% (2/63), natural conception 8.2% (5/61). These results suggest that ART does not increase the risk of YCM in male offspring.

语种: 英语
所属项目编号: 2011CB944504 ; 2012BAI32B01
项目资助者: Major State Basic Research Development Program of the People&prime ; s Republic of China ; National Scientific and Technical Supporting Programs - Ministry of Science and Technology of China
WOS记录号: WOS:000340282800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66208
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynaecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Beijing Haidian Maternal & Child Hlth Hosp, Beijing 100080, Peoples R China

Recommended Citation:
Liu, Xiao-Hong,Yan, Li-Ying,Lu, Cui-Ling,et al. ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions[J]. REPRODUCTION FERTILITY AND DEVELOPMENT,2014,26(6):778-786.
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