IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions
Liu, Xiao-Hong1,2,3,4; Yan, Li-Ying1,2,3; Lu, Cui-Ling1,2,3; Li, Rong1,2,3; Zhu, Xiao-Hui1,2,3; Jin, Hong-Yan1,2,3; Zhang, Yan1,2,3; Zhang, Wen-Xin1,2,3; Gao, Su-Hong4; Qiao, Jie1,2,3
关键词assisted reproductive technology ICSI male infertility outcomes
刊名REPRODUCTION FERTILITY AND DEVELOPMENT
2014
DOI10.1071/RD13092
26期:6页:778-786
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology ; Reproductive Biology ; Zoology
研究领域[WOS]Developmental Biology ; Reproductive Biology ; Zoology
关键词[WOS]INTRACYTOPLASMIC SPERM INJECTION ; DEPENDENT PROBE AMPLIFICATION ; IN-VITRO FERTILIZATION ; OF-THE-ART ; INFERTILE MEN ; VERTICAL TRANSMISSION ; PRENATAL-DIAGNOSIS ; FOLLOW-UP ; DELETIONS ; CHILDREN
英文摘要

Y-chromosome microdeletions (YCMs) have been found at a much higher rate in infertile men than fertile controls. Aspecific deletion in the azoospermia factor locus (AZF) at Yq11 is significantly associated with male infertility. Whether assisted reproductive technology (ART) increases the risk of YCM in ART-derived offspring remains unclear. In this study the occurrence of YCM in 199 fathers and their 228 sons (Chinese, Han ethnicity), including 85 offspring conceived by IVF, 73 by intra-cytoplasmic sperm injection (ICSI) and 70 by natural conception, was investigated. Nineteen candidate genes related to YCM were analysed by multiplex ligation-dependent probe amplification. We identified one de novo YCM from 70 naturally-conceived offspring and none from 158 ART-conceived offspring and found no statistical significance between these two groups. There was no statistically-significant difference in the detection rate of the father′s Y-chromosome microdeletion group: IVF 10.7% (8/75), ICSI 3.2% (2/63), natural conception 8.2% (5/61). These results suggest that ART does not increase the risk of YCM in male offspring.

语种英语
WOS记录号WOS:000340282800002
项目编号2011CB944504 ; 2012BAI32B01
资助机构Major State Basic Research Development Program of the People&prime ; s Republic of China ; National Scientific and Technical Supporting Programs - Ministry of Science and Technology of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66208
专题北京大学第三临床医学院_生殖医学中心
北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynaecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Beijing Haidian Maternal & Child Hlth Hosp, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xiao-Hong,Yan, Li-Ying,Lu, Cui-Ling,et al. ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions[J]. REPRODUCTION FERTILITY AND DEVELOPMENT,2014,26(6):778-786.
APA Liu, Xiao-Hong.,Yan, Li-Ying.,Lu, Cui-Ling.,Li, Rong.,Zhu, Xiao-Hui.,...&Qiao, Jie.(2014).ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions.REPRODUCTION FERTILITY AND DEVELOPMENT,26(6),778-786.
MLA Liu, Xiao-Hong,et al."ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions".REPRODUCTION FERTILITY AND DEVELOPMENT 26.6(2014):778-786.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Xiao-Hong]的文章
[Yan, Li-Ying]的文章
[Lu, Cui-Ling]的文章
百度学术
百度学术中相似的文章
[Liu, Xiao-Hong]的文章
[Yan, Li-Ying]的文章
[Lu, Cui-Ling]的文章
必应学术
必应学术中相似的文章
[Liu, Xiao-Hong]的文章
[Yan, Li-Ying]的文章
[Lu, Cui-Ling]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。