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学科主题基础医学
Hourglass-Like Constrictions of Peripheral Nerve in the Upper Extremity: A Clinical Review and Pathological Study
Pan, Yongwei1; Wang, Shufeng1; Zheng, Danfeng2; Tian, Wen1; Tian, Guanglei1; Ho, Pak Cheong3; Cheng, Hi-shan3; Zhong, Yanfeng2
关键词Hourglass-like constriction Nerve palsy Neuralgic amyotrophy Parsonage-Turner syndrome Pathology
刊名NEUROSURGERY
2014-07-01
DOI10.1227/NEU.0000000000000350
75期:1页:10-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Surgery
研究领域[WOS]Neurosciences & Neurology ; Surgery
关键词[WOS]POSTERIOR INTEROSSEOUS NERVE ; BRACHIAL-PLEXUS NEUROPATHY ; NEURALGIC AMYOTROPHY ; FASCICULAR CONSTRICTION ; MEDIAN NERVE ; RADIAL NERVE ; MULTIPLE CONSTRICTIONS ; HEREDITARY NEUROPATHY ; EXTERNAL COMPRESSION ; PRESSURE PALSIES
英文摘要

BACKGROUND:The development of an hourglass-like constriction in the nerve is rare, and its origin is unknown. Its clinical manifestations are not well documented, and the treatment protocol has not been established.OBJECTIVE:To identify the cause, presentation, and possible treatment for patients with nerve palsies secondary to an hourglass-like constriction in the affected nerves.METHODS:Patients presenting with peripheral nerve palsy caused by an hourglass-like constriction of nerves were retrospectively investigated in 2 hand centers. The patients′ presentation and neurological findings were reviewed, and the immunohistochemistry of excised specimens was studied.RESULTS:Forty-two patients who presented with 47 nerve palsies were examined. Forty-one patients experienced a sudden onset of pain in the upper limb, followed by flaccid paralysis in the affected muscles. Ten patients had multiple nerve involvement. Surgical exploration found 1 or more hourglass-like constrictions in the nerve. The treatments included internal neurolysis, neurorrhaphy, and nerve grafting. Thirty-one of 42 patients (36 nerves) were followed up for a mean of 48 months (range, 8-157 months). Fifteen of 16 nerves treated by neurolysis, 10 of 13 nerves treated by neurorrhaphy, and 4 of 7 nerves treated by nerve grafting had good recovery. CD8-positive T-lymphocyte infiltration was observed in all the excised specimens.CONCLUSION:The clinical presentation of patients with hourglass-like constrictions in their nerves is similar to that of patients with neuralgic amyotrophy. Histochemical analysis suggests that the pathogenesis may be immunological in origin. The role of surgery in this condition is uncertain.

语种英语
WOS记录号WOS:000337725100005
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/66211
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
2.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
3.Beijing Jishuitan Hosp, Dept Hand Surg, Beijing 100035, Peoples R China
推荐引用方式
GB/T 7714
Pan, Yongwei,Wang, Shufeng,Zheng, Danfeng,et al. Hourglass-Like Constrictions of Peripheral Nerve in the Upper Extremity: A Clinical Review and Pathological Study[J]. NEUROSURGERY,2014,75(1):10-21.
APA Pan, Yongwei.,Wang, Shufeng.,Zheng, Danfeng.,Tian, Wen.,Tian, Guanglei.,...&Zhong, Yanfeng.(2014).Hourglass-Like Constrictions of Peripheral Nerve in the Upper Extremity: A Clinical Review and Pathological Study.NEUROSURGERY,75(1),10-21.
MLA Pan, Yongwei,et al."Hourglass-Like Constrictions of Peripheral Nerve in the Upper Extremity: A Clinical Review and Pathological Study".NEUROSURGERY 75.1(2014):10-21.
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