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学科主题: 临床医学
题名:
Efficacy and safety of rivaroxaban versus low-molecular-weight heparin therapy in patients with lower limb fractures
作者: Long, Anhua1,2; Zhang, Lihai1; Zhang, Yingze3; Jiang, Baoguo4; Mao, Zhi1; Li, Hongda2; Zhang, Shanbao2; Xie, Zongyan2; Tang, Peifu1
关键词: Deep vein thrombosis ; Venous thromboembolism ; Major bleeding events ; Thromboprophylaxis ; Rivaroxaban ; Low-molecular-weight heparin
刊名: JOURNAL OF THROMBOSIS AND THROMBOLYSIS
发表日期: 2014-10-01
DOI: 10.1007/s11239-013-1046-1
卷: 38, 期:3, 页:299-305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: TOTAL KNEE ARTHROPLASTY ; DEEP-VEIN THROMBOSIS ; VENOUS THROMBOEMBOLISM ; ORTHOPEDIC-SURGERY ; HIP-ARTHROPLASTY ; THROMBOPROPHYLAXIS ; ENOXAPARIN ; TRIAL
英文摘要:

Thromboprophylaxis with rivaroxaban has proved effective and safe in patients undergoing hip and knee replacement surgery. As it is unclear whether it is also effective and safe in fracture patients, the aim of the present study was to evaluate the efficacy and safety of rivaroxaban in patients with lower limb fractures. We performed a retrospective cohort study of 2,050 consecutive patients treated for lower limb fractures at our trauma center, comparing rates of venous thromboembolism (VTE), bleeding and surgical complications, and the length of hospital stay for 608 patients who received rivaroxaban and 717 who received a low-molecular-weight heparin (LMWH). Rates of symptomatic VTE were 4.9 and 8.6 % in the rivaroxaban and LMWH groups, respectively (p = 0.008), and distal VTE rates were 1.8 and 5.7 %, respectively (p = 0.036). The incidence of major bleeding events in the rivaroxaban group was also lower than in the LMWH group (0.2 vs 0.6 %), but the difference between the groups was not statistically significant. The mean length of hospital stay was significantly shorter in the rivaroxaban group (12.2 vs 13.1 days, respectively; p = 0.016). This retrospective cohort study is the first report documenting the efficacy and safety of rivaroxaban in patients with lower extremity fractures. In comparison with LMWH, rivaroxaban reduced the incidence of VTE by 45 % without increasing the risk of bleeding. However, prospective, randomized controlled trials comparing rivaroxaban and LMWH are needed to confirm our findings.

语种: 英语
WOS记录号: WOS:000341085300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66212
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
2.Hebei Med Univ, Hosp 1, Dept Orthoped, Shijiazhuang 050031, Hebei Province, Peoples R China
3.Nankai Univ, Sch Med, Tianjin 300071, Peoples R China
4.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Long, Anhua,Zhang, Lihai,Zhang, Yingze,et al. Efficacy and safety of rivaroxaban versus low-molecular-weight heparin therapy in patients with lower limb fractures[J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS,2014,38(3):299-305.
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