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学科主题: 临床医学
题名:
Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma
作者: Lan, FengMing1; Pan, Qiang2; Yu, Huiming3; Yue, Xiao4
关键词: apoptosis ; glioblastoma ; miR-21 ; sulforaphane ; temozolomide ; Wnt ; -catenin signaling
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2015-09-01
DOI: 10.1111/jnc.13174
卷: 134, 期:5, 页:811-818
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: CELL-LINES ; MALIGNANT GLIOBLASTOMA ; U87MG CELLS ; STEM-CELLS ; CANCER ; PROMOTES ; RESISTANCE ; CARCINOMA ; GLIOMAS ; BREAST
英文摘要:

Temozolomide (TMZ) has been widely used in the treatment of glioblastoma (GBM), although inherent or acquired resistance restricts the application. This study was aimed to evaluate the efficacy of sulforaphane (SFN) to TMZ-induced apoptosis in GBM cells and the potential mechanism. Biochemical assays and subcutaneous tumor establishment were used to characterize the function of SFN in TMZ-induced apoptosis. Our results revealed that -catenin and miR-21 were concordantly expressed in GBM cell lines, and SFN significantly reduced miR-21 expression through inhibiting the Wnt/-catenin/TCF4 pathway. Furthermore, down-regulation of miR-21 enhanced the pro-apoptotic efficacy of TMZ in GBM cells. Finally, we observed that SFN strengthened TMZ-mediated apoptosis in a miR-21-dependent manner. In conclusion, SFN effectively enhances TMZ-induced apoptosis by inhibiting miR-21 via Wnt/-catenin signaling in GBM cells. These findings support the use of SFN for potential therapeutic approach to overcome TMZ resistance in GBM treatment.

语种: 英语
所属项目编号: 81201973 ; 81172596 ; 81482814
项目资助者: China National Natural Scientific Fund
WOS记录号: WOS:000359383500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66215
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ Canc Hosp & Inst, Dept Radiotherapy, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China
2.Tianjin Neurosurg Inst, Tianjin Huanhu Hosp, Tianjin Key Lab Cerebral Vasc & Neurodegenerat Di, Tianjin 300060, Peoples R China
3.Tianjin Hosp, Dept Radiat Oncol, Tianjin, Peoples R China
4.Laiwu City Peoples Hosp, Dept Neurosurg, Laiwu, Shandong, Peoples R China

Recommended Citation:
Lan, FengMing,Pan, Qiang,Yu, Huiming,et al. Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma[J]. JOURNAL OF NEUROCHEMISTRY,2015,134(5):811-818.
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