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学科主题临床医学
Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma
Lan, FengMing1; Pan, Qiang2; Yu, Huiming3; Yue, Xiao4
关键词apoptosis glioblastoma miR-21 sulforaphane temozolomide Wnt -catenin signaling
刊名JOURNAL OF NEUROCHEMISTRY
2015-09-01
DOI10.1111/jnc.13174
134期:5页:811-818
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]CELL-LINES ; MALIGNANT GLIOBLASTOMA ; U87MG CELLS ; STEM-CELLS ; CANCER ; PROMOTES ; RESISTANCE ; CARCINOMA ; GLIOMAS ; BREAST
英文摘要

Temozolomide (TMZ) has been widely used in the treatment of glioblastoma (GBM), although inherent or acquired resistance restricts the application. This study was aimed to evaluate the efficacy of sulforaphane (SFN) to TMZ-induced apoptosis in GBM cells and the potential mechanism. Biochemical assays and subcutaneous tumor establishment were used to characterize the function of SFN in TMZ-induced apoptosis. Our results revealed that -catenin and miR-21 were concordantly expressed in GBM cell lines, and SFN significantly reduced miR-21 expression through inhibiting the Wnt/-catenin/TCF4 pathway. Furthermore, down-regulation of miR-21 enhanced the pro-apoptotic efficacy of TMZ in GBM cells. Finally, we observed that SFN strengthened TMZ-mediated apoptosis in a miR-21-dependent manner. In conclusion, SFN effectively enhances TMZ-induced apoptosis by inhibiting miR-21 via Wnt/-catenin signaling in GBM cells. These findings support the use of SFN for potential therapeutic approach to overcome TMZ resistance in GBM treatment.

语种英语
WOS记录号WOS:000359383500003
项目编号81201973 ; 81172596 ; 81482814
资助机构China National Natural Scientific Fund
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66215
专题北京大学临床肿瘤学院
作者单位1.Peking Univ Canc Hosp & Inst, Dept Radiotherapy, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China
2.Tianjin Neurosurg Inst, Tianjin Huanhu Hosp, Tianjin Key Lab Cerebral Vasc & Neurodegenerat Di, Tianjin 300060, Peoples R China
3.Tianjin Hosp, Dept Radiat Oncol, Tianjin, Peoples R China
4.Laiwu City Peoples Hosp, Dept Neurosurg, Laiwu, Shandong, Peoples R China
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Lan, FengMing,Pan, Qiang,Yu, Huiming,et al. Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma[J]. JOURNAL OF NEUROCHEMISTRY,2015,134(5):811-818.
APA Lan, FengMing,Pan, Qiang,Yu, Huiming,&Yue, Xiao.(2015).Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma.JOURNAL OF NEUROCHEMISTRY,134(5),811-818.
MLA Lan, FengMing,et al."Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/-catenin signaling in glioblastoma".JOURNAL OF NEUROCHEMISTRY 134.5(2015):811-818.
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