北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肾内科  > 期刊论文
学科主题: 临床医学
题名:
Irisin levels are associated with urotensin II levels in diabetic patients
作者: He, Wan-Yu1; Bai, Qiong1; La-Ta, A.1; Tang, Chao-Shu2; Zhang, Ai-Hua1
关键词: Irisin ; Type 2 diabetes ; Urotensin II
刊名: JOURNAL OF DIABETES INVESTIGATION
发表日期: 2015-09-01
DOI: 10.1111/jdi.12331
卷: 6, 期:5, 页:571-576
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CIRCULATING IRISIN ; MELLITUS
英文摘要:

Aims/IntroductionIrisin is a newly identified myokine that can promote energy expenditure. Previous studies showed that circulating urotensin II (UII) levels were increased in diabetes, and UII could inhibit the glucose transport in skeletal muscle in diabetic mice and aggravated insulin resistance. We presumed that irisin levels are associated with UII in diabetic patients.

Materials and MethodsA total of 71 patients with type 2 diabetes and 40 healthy subjects were recruited. Blood and urinary irisin concentrations were measured by using enzyme-linked immunosorbent assay, and UII concentrations were measured by bioelectrical impedance analysis. Every participant′s body composition was analyzed by bioelectrical impedance.

ResultsThe serum irisin levels were significantly lower in diabetic patients than that of controls, whereas serum UII levels were significantly higher in diabetic patients than that in that of controls. Serum irisin levels were negatively associated with circulating UII, hemoglobin A1c and the natural logarithm transformation of urinary albumin excretion, whereas serum irisin was positively associated with estimated glomerular filtration rate, and low-density lipoprotein cholesterol and urinary irisin were positively associated with urinary UII. Furthermore, circulating irisin is positively associated with muscle mass, whereas circulating UII is negatively associated with muscle mass in diabetic patients. Hemoglobin A1c and circulating UII are independent determinants of circulating irisin by multiple regression analysis.

ConclusionsThe present results provide the clinical evidence of an association between irisin and UII in diabetic patients. Hemoglobin A1c and circulating UII are independent determinants of circulating irisin. Our results hint that UII and high glucose might inhibit the release of irisin from skeletal muscle in diabetic patients.

语种: 英语
所属项目编号: 81170706 ; 81341022 ; SCW 2009-8
项目资助者: National Natural Science Foundation ; Beijing Municipal Science &amp ; technology commission
WOS记录号: WOS:000360810800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66216
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol & Physiol, Beijing 100871, Peoples R China

Recommended Citation:
He, Wan-Yu,Bai, Qiong,La-Ta, A.,et al. Irisin levels are associated with urotensin II levels in diabetic patients[J]. JOURNAL OF DIABETES INVESTIGATION,2015,6(5):571-576.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He, Wan-Yu]'s Articles
[Bai, Qiong]'s Articles
[La-Ta, A.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He, Wan-Yu]‘s Articles
[Bai, Qiong]‘s Articles
[La-Ta, A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace