|Irisin levels are associated with urotensin II levels in diabetic patients|
|He, Wan-Yu1; Bai, Qiong1; La-Ta, A.1; Tang, Chao-Shu2; Zhang, Ai-Hua1|
|关键词||Irisin Type 2 diabetes Urotensin II|
|刊名||JOURNAL OF DIABETES INVESTIGATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||CIRCULATING IRISIN ; MELLITUS|
Aims/IntroductionIrisin is a newly identified myokine that can promote energy expenditure. Previous studies showed that circulating urotensin II (UII) levels were increased in diabetes, and UII could inhibit the glucose transport in skeletal muscle in diabetic mice and aggravated insulin resistance. We presumed that irisin levels are associated with UII in diabetic patients.
Materials and MethodsA total of 71 patients with type 2 diabetes and 40 healthy subjects were recruited. Blood and urinary irisin concentrations were measured by using enzyme-linked immunosorbent assay, and UII concentrations were measured by bioelectrical impedance analysis. Every participant′s body composition was analyzed by bioelectrical impedance.
ResultsThe serum irisin levels were significantly lower in diabetic patients than that of controls, whereas serum UII levels were significantly higher in diabetic patients than that in that of controls. Serum irisin levels were negatively associated with circulating UII, hemoglobin A1c and the natural logarithm transformation of urinary albumin excretion, whereas serum irisin was positively associated with estimated glomerular filtration rate, and low-density lipoprotein cholesterol and urinary irisin were positively associated with urinary UII. Furthermore, circulating irisin is positively associated with muscle mass, whereas circulating UII is negatively associated with muscle mass in diabetic patients. Hemoglobin A1c and circulating UII are independent determinants of circulating irisin by multiple regression analysis.
ConclusionsThe present results provide the clinical evidence of an association between irisin and UII in diabetic patients. Hemoglobin A1c and circulating UII are independent determinants of circulating irisin. Our results hint that UII and high glucose might inhibit the release of irisin from skeletal muscle in diabetic patients.
|项目编号||81170706 ; 81341022 ; SCW 2009-8|
|资助机构||National Natural Science Foundation ; Beijing Municipal Science & ; technology commission|
|作者单位||1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Dept Pathol & Physiol, Beijing 100871, Peoples R China
|He, Wan-Yu,Bai, Qiong,La-Ta, A.,et al. Irisin levels are associated with urotensin II levels in diabetic patients[J]. JOURNAL OF DIABETES INVESTIGATION,2015,6(5):571-576.|
|APA||He, Wan-Yu,Bai, Qiong,La-Ta, A.,Tang, Chao-Shu,&Zhang, Ai-Hua.(2015).Irisin levels are associated with urotensin II levels in diabetic patients.JOURNAL OF DIABETES INVESTIGATION,6(5),571-576.|
|MLA||He, Wan-Yu,et al."Irisin levels are associated with urotensin II levels in diabetic patients".JOURNAL OF DIABETES INVESTIGATION 6.5(2015):571-576.|