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学科主题: 公共卫生
题名:
Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample
作者: Liu, Qingqing1; Yu, Canqing1; Gao, Wenjing1; Cao, Weihua1; Lyu, Jun1; Wang, Shengfeng1; Pang, Zengchang2; Cong, Liming3; Dong, Zhong4; Wu, Fan5; Wang, Hua6; Wu, Xianping7; Jiang, Guohong8; Wang, Binyou9; Li, Liming1
关键词: height ; weight ; BMI ; heritability ; twin study
刊名: TWIN RESEARCH AND HUMAN GENETICS
发表日期: 2015-10-01
DOI: 10.1017/thg.2015.63
卷: 18, 期:5, 页:571-580
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]: BODY-MASS INDEX ; PARENTAL FEEDING PRACTICES ; BIRTH-COHORT ; FTO GENE ; CHILDHOOD OBESITY ; CHILDREN ; HERITABILITY ; ASSOCIATIONS ; ADOLESCENCE ; RISK
英文摘要:

This study examined the genetic and environmental effects on variances in weight, height, and body mass index (BMI) under 18 years in a population-based sample from China. We selected 6,644 monozygotic and 5,969 dizygotic twin pairs from the Chinese National Twin Registry (CNTR) aged under 18 years (n = 12,613). Classic twin analyses with sex limitation were used to estimate the genetic and environmental components of weight, height, and BMI in six age groups. Sex-limitation of genetic and shared environmental effects was observed, especially when puberty begins. Heritability for weight, height, and BMI was low at 0-2 years old (less than 20% for both sexes) but increased over time, accounting for half or more of the variance in the 15-17 year age group for boys. For girls, heritabilities for weight, height and BMI was maintained at approximately 30% after puberty. Common environmental effects on all body measures were high for girls (59-87%) and presented a small peak during puberty. Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in the pre-adolescent period and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. Further studies about puberty-related genes and social environment are needed to clarify the mechanism of sex differences.

语种: 英语
所属项目编号: 201002007
项目资助者: Specific Research Project of Health Public Service, Ministry of Health, China
WOS记录号: WOS:000361660800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66218
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China
2.Jiangsu Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China
3.Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China
4.Harbin Med Univ, Sch Publ Hlth, Harbin, Peoples R China
5.Zhejiang Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China
6.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
7.Beijing Ctr Dis Control & Prevent, Dept Chron & Noncommunicable Dis Control & Preven, Beijing, Peoples R China
8.Tianjin Ctr Dis Control & Prevent, Dept Chron & Noncommunicable Dis Control & Preven, Tianjin, Peoples R China
9.Qingdao Ctr Dis Control & Prevent, Qingdao, Peoples R China

Recommended Citation:
Liu, Qingqing,Yu, Canqing,Gao, Wenjing,et al. Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample[J]. TWIN RESEARCH AND HUMAN GENETICS,2015,18(5):571-580.
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