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Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample
Liu, Qingqing1; Yu, Canqing1; Gao, Wenjing1; Cao, Weihua1; Lyu, Jun1; Wang, Shengfeng1; Pang, Zengchang2; Cong, Liming3; Dong, Zhong4; Wu, Fan5; Wang, Hua6; Wu, Xianping7; Jiang, Guohong8; Wang, Binyou9; Li, Liming1
关键词height weight BMI heritability twin study
刊名TWIN RESEARCH AND HUMAN GENETICS
2015-10-01
DOI10.1017/thg.2015.63
18期:5页:571-580
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]BODY-MASS INDEX ; PARENTAL FEEDING PRACTICES ; BIRTH-COHORT ; FTO GENE ; CHILDHOOD OBESITY ; CHILDREN ; HERITABILITY ; ASSOCIATIONS ; ADOLESCENCE ; RISK
英文摘要

This study examined the genetic and environmental effects on variances in weight, height, and body mass index (BMI) under 18 years in a population-based sample from China. We selected 6,644 monozygotic and 5,969 dizygotic twin pairs from the Chinese National Twin Registry (CNTR) aged under 18 years (n = 12,613). Classic twin analyses with sex limitation were used to estimate the genetic and environmental components of weight, height, and BMI in six age groups. Sex-limitation of genetic and shared environmental effects was observed, especially when puberty begins. Heritability for weight, height, and BMI was low at 0-2 years old (less than 20% for both sexes) but increased over time, accounting for half or more of the variance in the 15-17 year age group for boys. For girls, heritabilities for weight, height and BMI was maintained at approximately 30% after puberty. Common environmental effects on all body measures were high for girls (59-87%) and presented a small peak during puberty. Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in the pre-adolescent period and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. Further studies about puberty-related genes and social environment are needed to clarify the mechanism of sex differences.

语种英语
WOS记录号WOS:000361660800009
项目编号201002007
资助机构Specific Research Project of Health Public Service, Ministry of Health, China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66218
专题北京大学公共卫生学院
作者单位1.Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China
2.Jiangsu Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China
3.Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China
4.Harbin Med Univ, Sch Publ Hlth, Harbin, Peoples R China
5.Zhejiang Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China
6.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
7.Beijing Ctr Dis Control & Prevent, Dept Chron & Noncommunicable Dis Control & Preven, Beijing, Peoples R China
8.Tianjin Ctr Dis Control & Prevent, Dept Chron & Noncommunicable Dis Control & Preven, Tianjin, Peoples R China
9.Qingdao Ctr Dis Control & Prevent, Qingdao, Peoples R China
推荐引用方式
GB/T 7714
Liu, Qingqing,Yu, Canqing,Gao, Wenjing,et al. Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample[J]. TWIN RESEARCH AND HUMAN GENETICS,2015,18(5):571-580.
APA Liu, Qingqing.,Yu, Canqing.,Gao, Wenjing.,Cao, Weihua.,Lyu, Jun.,...&Li, Liming.(2015).Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample.TWIN RESEARCH AND HUMAN GENETICS,18(5),571-580.
MLA Liu, Qingqing,et al."Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample".TWIN RESEARCH AND HUMAN GENETICS 18.5(2015):571-580.
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