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学科主题: 基础医学
题名:
Calcitonin gene-related peptide partially reverses decreased production of chemokines KC and MIP-2 following murine sepsis
作者: Wang, X; Ebong, SJ; Call, DR; Newcomb, DE; Bolgos, GR; Remick, DG
关键词: calcitonin ; chemokines ; murine sepsis
刊名: INFLAMMATION
发表日期: 2002-08-01
卷: 26, 期:4, 页:167-174
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; GROWTH-FACTOR ; MACROPHAGES ; CGRP ; RECEPTORS ; MEDIATORS ; RAT ; LIPOPOLYSACCHARIDE ; INTERLEUKIN-8 ; NEUROPEPTIDE
英文摘要:

The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP). Macrophages were obtained from the peritoneal exudate and lung of female BALB/c mice 16 h after CLP and plated in culture with CGRP and/or LPS for 12 h. The results showed that peritoneal macrophage production of the chemokines (KC, MIP-2) and cytokines (TNF-alpha, IL-6) was markedly decreased in CLP mice. Alveolar macrophages did not display decreased cytokine/chemokines production after CLP. CGRP (0.1 nM-10 nM) partially reversed this decreased production of LPS-induced KC and MIP-2 from peritoneal macrophages. These results suggest that CGRP might be intimately involved in recruitment of neutrophils by promoting local production of the chemokines KC and MIP-2 in murine sepsis.

语种: 英语
WOS记录号: WOS:000177035800004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66220
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: 1.Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, X,Ebong, SJ,Call, DR,et al. Calcitonin gene-related peptide partially reverses decreased production of chemokines KC and MIP-2 following murine sepsis[J]. INFLAMMATION,2002,26(4):167-174.
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