IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter
Wang, RS; Huo, Y; Chen, M; Liu, ZP; Zhu, GY
关键词brachytherapy restenosis interventional therapy
刊名CHINESE MEDICAL JOURNAL
2000-03-01
113期:3页:225-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INTRACORONARY RADIATION ; NEOINTIMAL HYPERPLASIA ; REDUCE RESTENOSIS ; BETA-IRRADIATION ; ANGIOPLASTY ; THERAPY
英文摘要

Objective To observe the effect of endovascular brachytherapy on the prevention of restenosis after interveneional therapy and to investigate its possible mechanisms.

Methods In the balloon-injuried rabbit model, pathological sections of iliac arteries were observed and the changes of vascular histomorphology were estimated by computer analysis of photomicrograms. Using immunohistochemical techniques, proliferating cell nuclear antigen (PCNA) was quantified to assess the proliferation of vascular smooth muscle cells.

Results After rabbit iliac arteries were injured by balloon overstretch angioplasty, neointima were shown to be less proliferative in the irradiated group than in the control group, from PCNA scores. The formation of neointima was suppressed with the external elastic laminar area increasing and without the luminal area decreasing in the irradiation group.

Conclusion Endovascular brachytherapy using a liquid P-32 filled balloon catheter system could prevent restenosis possibly by inhibiting the formation of neointima and improving positive vascular remodeling.

语种英语
WOS记录号WOS:000087103400009
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66221
专题北京大学第一临床医学院
作者单位Beijing Med Univ, Teaching Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, RS,Huo, Y,Chen, M,et al. An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter[J]. CHINESE MEDICAL JOURNAL,2000,113(3):225-227.
APA Wang, RS,Huo, Y,Chen, M,Liu, ZP,&Zhu, GY.(2000).An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter.CHINESE MEDICAL JOURNAL,113(3),225-227.
MLA Wang, RS,et al."An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter".CHINESE MEDICAL JOURNAL 113.3(2000):225-227.
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