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学科主题: 临床医学
题名:
An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter
作者: Wang, RS; Huo, Y; Chen, M; Liu, ZP; Zhu, GY
关键词: brachytherapy ; restenosis ; interventional therapy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2000-03-01
卷: 113, 期:3, 页:225-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INTRACORONARY RADIATION ; NEOINTIMAL HYPERPLASIA ; REDUCE RESTENOSIS ; BETA-IRRADIATION ; ANGIOPLASTY ; THERAPY
英文摘要:

Objective To observe the effect of endovascular brachytherapy on the prevention of restenosis after interveneional therapy and to investigate its possible mechanisms.

Methods In the balloon-injuried rabbit model, pathological sections of iliac arteries were observed and the changes of vascular histomorphology were estimated by computer analysis of photomicrograms. Using immunohistochemical techniques, proliferating cell nuclear antigen (PCNA) was quantified to assess the proliferation of vascular smooth muscle cells.

Results After rabbit iliac arteries were injured by balloon overstretch angioplasty, neointima were shown to be less proliferative in the irradiated group than in the control group, from PCNA scores. The formation of neointima was suppressed with the external elastic laminar area increasing and without the luminal area decreasing in the irradiation group.

Conclusion Endovascular brachytherapy using a liquid P-32 filled balloon catheter system could prevent restenosis possibly by inhibiting the formation of neointima and improving positive vascular remodeling.

语种: 英语
WOS记录号: WOS:000087103400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66221
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Beijing Med Univ, Teaching Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang, RS,Huo, Y,Chen, M,et al. An experimental study of endovascular brachytherapy using liquid P-32 filled balloon catheter[J]. CHINESE MEDICAL JOURNAL,2000,113(3):225-227.
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