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学科主题口腔医学
Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
Zhang, Xin1,2; Meng, Huanxin1; Xu, Li1; Zhang, Li1; Shi, Dong1; Feng, Xianghui1; Lu, Ruifang1; Chen, Zhibin1
刊名INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
2014
DOI10.1155/2014/783575
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]RECEPTOR GENE POLYMORPHISM ; GC-GLOBULIN ; ASSOCIATION ; ELEVATION ; DISEASES
英文摘要

Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP), in comparison to healthy controls, with the goal of elucidating the relationship between DBP and GAgP. Fifty-nine GAgP patients and 58 healthy controls were recruited for the study; clinical parameters of probing depths (PD), bleeding index, and attachment loss (AL) were recorded. DBP levels were measured by enzyme-linked immunosorbent assay. From the results, GAgP patients had higher plasma DBP concentrations (P < 0.001) but lower GCF DBP concentrations (P < 0.001) than healthy controls. In GAgP group, after controlling the potential confounders of age, gender, smoking status, and BMI index, GCFDBP concentrations correlated negatively withPD(P < 0.001) andAL(P = 0.009). Within the limits of the study, we concluded that decreased GCF DBP level and increased plasma DBP level are associated with periodontitis.

语种英语
WOS记录号WOS:000336275900001
项目编号30271411 ; 30471882 ; 30772420 ; 30973319 ; 81271149 ; 2002AA217091 ; 2007BAZ18B02
资助机构National Natural Science Foundations of China ; National Key Project of Scientific and Technical Supporting Programs of China ; Clinical Research Fund, Ministry of Health P.R.C
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66225
专题北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xin,Meng, Huanxin,Xu, Li,et al. Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2014.
APA Zhang, Xin.,Meng, Huanxin.,Xu, Li.,Zhang, Li.,Shi, Dong.,...&Chen, Zhibin.(2014).Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis.INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.
MLA Zhang, Xin,et al."Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis".INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2014).
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