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学科主题: 口腔医学
题名:
Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
作者: Zhang, Xin1,2; Meng, Huanxin1; Xu, Li1; Zhang, Li1; Shi, Dong1; Feng, Xianghui1; Lu, Ruifang1; Chen, Zhibin1
刊名: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
发表日期: 2014
DOI: 10.1155/2014/783575
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: RECEPTOR GENE POLYMORPHISM ; GC-GLOBULIN ; ASSOCIATION ; ELEVATION ; DISEASES
英文摘要:

Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP), in comparison to healthy controls, with the goal of elucidating the relationship between DBP and GAgP. Fifty-nine GAgP patients and 58 healthy controls were recruited for the study; clinical parameters of probing depths (PD), bleeding index, and attachment loss (AL) were recorded. DBP levels were measured by enzyme-linked immunosorbent assay. From the results, GAgP patients had higher plasma DBP concentrations (P < 0.001) but lower GCF DBP concentrations (P < 0.001) than healthy controls. In GAgP group, after controlling the potential confounders of age, gender, smoking status, and BMI index, GCFDBP concentrations correlated negatively withPD(P < 0.001) andAL(P = 0.009). Within the limits of the study, we concluded that decreased GCF DBP level and increased plasma DBP level are associated with periodontitis.

语种: 英语
所属项目编号: 30271411 ; 30471882 ; 30772420 ; 30973319 ; 81271149 ; 2002AA217091 ; 2007BAZ18B02
项目资助者: National Natural Science Foundations of China ; National Key Project of Scientific and Technical Supporting Programs of China ; Clinical Research Fund, Ministry of Health P.R.C
WOS记录号: WOS:000336275900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66225
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China

Recommended Citation:
Zhang, Xin,Meng, Huanxin,Xu, Li,et al. Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2014.
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