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Efficacy and Safety of Neoadjuvant Intensity-Modulated Radiotherapy With Concurrent Capecitabine for Locally Advanced Rectal Cancer
Wang, Lin1; Li, Zi-Yu2; Li, Zhong-Wu3; Li, Yong-Heng4; Sun, Ying-Shi5; Ji, Jia-Fu2; Gu, Jin1; Cai, Yong4
关键词Intensity-modulated radiotherapy Rectal cancer Neoadjuvant Toxicity Complication
刊名DISEASES OF THE COLON & RECTUM
2015-02-01
DOI10.1097/DCR.0000000000000294
58期:2页:186-192
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]TOTAL MESORECTAL EXCISION ; COMBINED-MODALITY THERAPY ; PHASE-III TRIAL ; PREOPERATIVE RADIOTHERAPY ; SURGICAL COMPLICATIONS ; CONFORMAL RADIOTHERAPY ; ORAL CAPECITABINE ; CHEMORADIOTHERAPY ; OXALIPLATIN ; CARCINOMA
英文摘要

BACKGROUND: We previously conducted a prospective phase II clinical trial studying a unique 22-fraction neoadjuvant intensity-modulated radiotherapy with concurrent capecitabine treatment followed by total mesorectal excision for locally advanced rectal cancer.

OBJECTIVE: The objective of this study was to retrospectively review the efficacy, toxicity, and surgical complications following intensity-modulated radiotherapy in patients who have rectal cancer.

DESIGN: This was a retrospective study.

SETTING: Data were gathered from a surgical database.

PATIENTS: This study included patients who underwent intensity-modulated radiotherapy with gross tumor volume/clinical target volume of 50.6/41.8 Gy in 22 fractions with concurrent capecitabine treatment over a period of 30 days, after which the patients underwent surgery for rectal cancer in Peking University Cancer Hospital (2007-2013).

MAIN OUTCOME MEASURES: The primary end points were acute toxicity, postoperative complications, and complete response rate.

RESULTS: A total of 260 patients were included in our analysis. The median age was 55 years (range, 21-87 years), and 68.5% of the patients were male. The yield complete response rate was 18.5% (48/260). There were no grade 4 toxicity and perioperative mortality. The grade 3 toxicity rate was 5.8%, which included diarrhea (4.2%), neutropenia (1.2%), and radiation dermatitis (0.4%). The 30-day postoperative and severe complication (>= grade 3) rates were 23.1% and 2.7%. The anastomotic leakage rate was 3.3% (5/152). Perineal wound complications (29.2%, 28/96) represented the most common problem following abdominoperineal resection. The estimated 3-year local recurrence-free survival, cancer-specific survival, and disease-free survival rates were 94.2% (95% CI, 90.1%98.3%), 92.2% (95% CI, 87.5%-97.0%), and 81.4% (95% CI, 75.4%-87.4%).

LIMITATION: The retrospective nature and the single-arm design was the limitation of the study.

CONCLUSION: The 22-fraction neoadjuvant intensity-modulated radiotherapy regimen used to treat rectal cancer in this study has a high efficacy rate and a low

语种英语
所属项目编号Z111107058811021 ; ZY201410
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
WOS记录号WOS:000348186000010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66230
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Peking Univ Canc Hosp, Dept Colorectal Surg, Beijing, Peoples R China
2.Peking Univ Canc Hosp, Dept Pathol, Beijing, Peoples R China
3.Peking Univ Canc Hosp, Dept Radiat Oncol, Beijing, Peoples R China
4.Peking Univ Canc Hosp, Dept Radiol, Beijing, Peoples R China
5.Peking Univ Canc Hosp, Dept Gastrointestinal Surg, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lin,Li, Zi-Yu,Li, Zhong-Wu,et al. Efficacy and Safety of Neoadjuvant Intensity-Modulated Radiotherapy With Concurrent Capecitabine for Locally Advanced Rectal Cancer[J]. DISEASES OF THE COLON & RECTUM,2015,58(2):186-192.
APA Wang, Lin.,Li, Zi-Yu.,Li, Zhong-Wu.,Li, Yong-Heng.,Sun, Ying-Shi.,...&Cai, Yong.(2015).Efficacy and Safety of Neoadjuvant Intensity-Modulated Radiotherapy With Concurrent Capecitabine for Locally Advanced Rectal Cancer.DISEASES OF THE COLON & RECTUM,58(2),186-192.
MLA Wang, Lin,et al."Efficacy and Safety of Neoadjuvant Intensity-Modulated Radiotherapy With Concurrent Capecitabine for Locally Advanced Rectal Cancer".DISEASES OF THE COLON & RECTUM 58.2(2015):186-192.
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