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学科主题: 临床医学
题名:
Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma
作者: Wu, Jin-yu2; Chen, Min-hua1; Yang, Wei1; Lin, Shu-zhi2; Wu, Wei1; Yin, Shan-shan1; Zhang, Hui1; Yan, Kun1
关键词: Contrast enhanced ultrasound (CEUS) ; Liver metastasis ; Radiofrequency ablation (RFA)
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2012-03-01
DOI: 10.1007/s11670-012-0044-8
卷: 24, 期:1, 页:44-51
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; HEPATIC METASTASES ; COLORECTAL-CANCER ; TUMOR ABLATION ; ULTRASONOGRAPHY ; MALIGNANCIES ; THERAPY
英文摘要:

To investigate the application of contrast enhanced ultrasound (CEUS) in planning and guiding for radiofrequency ablation (RFA) for metastatic liver carcinoma (MLC).

One hundred and thirty-five patients with clinically and pathologically diagnosed MLC (from gastrointestinal tumors) were included in the present study, and 104 of them had received CEUS prior to RFA to assess the number, size, shape, infiltration, location and enhancing features of the lesions. Among the 104 patients, 21 (20.1%) were excluded from RFA treatment due to too many lesions or large infiltrative range based on CEUS. The remaining 83 patients with 147 lesions underwent RFA (group A). During the same period, other 31 patients with 102 lesions serving as control group were treated based on findings of conventional ultrasound without contrast (group B). The patients underwent follow-up enhanced CT at the 1st month, and then every 3-6 months after RFA. The tumor was considered as early necrosis if no contrast enhancement was detected in the treated area on the CT scan at the 1st month.

In group A, 72 of 147 MLC lesions (48.9%) showed increased sizes on CEUS. Among them, 48 lesions (66.6%) appeared enlarged in arterial phase, and 24 (33.3%) showed enlarged hypoechoic area in parenchymal phase. CEUS showed total 61 additional lesions in 35 patients (42.1%) (ranged from 8 to 15 mm) compared with conventional ultrasound (US), and 42 (68.8%) of them were visualized in parenchymal phase only. There were total 208 lesions in group A underwent RFA with CEUS planning, and the tumor necrosis rate was 94.2% (196/208). In this group, local recurrence was found in 16 lesions (7.7%) during 3-42 months′ following up, and new metastases were seen in 30 cases (36.1%). For group B, the tumor necrosis rate was 86.3% (88/102), local recurrence in 17 lesions (16.7%), and new metastases in 13 cases (41.9%). Tumor early necrosis and recurrence rates were significantly different between the two groups (P=0.018, P=0.016, respectively).

CEUS played an important role in RFA for liver metastases by candidate selecting and therapy planning, which helped to improve the outcome of the treatment.

语种: 英语
所属项目编号: 81101745
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000300313500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66231
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Harbin First Hosp, Dept Ultrasound, Harbin 150010, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Ultrasound, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Wu, Jin-yu,Chen, Min-hua,Yang, Wei,et al. Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(1):44-51.
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