IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma
Wu, Jin-yu2; Chen, Min-hua1; Yang, Wei1; Lin, Shu-zhi2; Wu, Wei1; Yin, Shan-shan1; Zhang, Hui1; Yan, Kun1
关键词Contrast enhanced ultrasound (CEUS) Liver metastasis Radiofrequency ablation (RFA)
刊名CHINESE JOURNAL OF CANCER RESEARCH
2012-03-01
DOI10.1007/s11670-012-0044-8
24期:1页:44-51
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; HEPATIC METASTASES ; COLORECTAL-CANCER ; TUMOR ABLATION ; ULTRASONOGRAPHY ; MALIGNANCIES ; THERAPY
英文摘要

To investigate the application of contrast enhanced ultrasound (CEUS) in planning and guiding for radiofrequency ablation (RFA) for metastatic liver carcinoma (MLC).

One hundred and thirty-five patients with clinically and pathologically diagnosed MLC (from gastrointestinal tumors) were included in the present study, and 104 of them had received CEUS prior to RFA to assess the number, size, shape, infiltration, location and enhancing features of the lesions. Among the 104 patients, 21 (20.1%) were excluded from RFA treatment due to too many lesions or large infiltrative range based on CEUS. The remaining 83 patients with 147 lesions underwent RFA (group A). During the same period, other 31 patients with 102 lesions serving as control group were treated based on findings of conventional ultrasound without contrast (group B). The patients underwent follow-up enhanced CT at the 1st month, and then every 3-6 months after RFA. The tumor was considered as early necrosis if no contrast enhancement was detected in the treated area on the CT scan at the 1st month.

In group A, 72 of 147 MLC lesions (48.9%) showed increased sizes on CEUS. Among them, 48 lesions (66.6%) appeared enlarged in arterial phase, and 24 (33.3%) showed enlarged hypoechoic area in parenchymal phase. CEUS showed total 61 additional lesions in 35 patients (42.1%) (ranged from 8 to 15 mm) compared with conventional ultrasound (US), and 42 (68.8%) of them were visualized in parenchymal phase only. There were total 208 lesions in group A underwent RFA with CEUS planning, and the tumor necrosis rate was 94.2% (196/208). In this group, local recurrence was found in 16 lesions (7.7%) during 3-42 months′ following up, and new metastases were seen in 30 cases (36.1%). For group B, the tumor necrosis rate was 86.3% (88/102), local recurrence in 17 lesions (16.7%), and new metastases in 13 cases (41.9%). Tumor early necrosis and recurrence rates were significantly different between the two groups (P=0.018, P=0.016, respectively).

CEUS played an important role in RFA for liver metastases by candidate selecting and therapy planning, which helped to improve the outcome of the treatment.

语种英语
所属项目编号81101745
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000300313500007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66231
专题北京大学临床肿瘤学院
作者单位1.Harbin First Hosp, Dept Ultrasound, Harbin 150010, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Ultrasound, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Wu, Jin-yu,Chen, Min-hua,Yang, Wei,et al. Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(1):44-51.
APA Wu, Jin-yu.,Chen, Min-hua.,Yang, Wei.,Lin, Shu-zhi.,Wu, Wei.,...&Yan, Kun.(2012).Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,24(1),44-51.
MLA Wu, Jin-yu,et al."Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 24.1(2012):44-51.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, Jin-yu]的文章
[Chen, Min-hua]的文章
[Yang, Wei]的文章
百度学术
百度学术中相似的文章
[Wu, Jin-yu]的文章
[Chen, Min-hua]的文章
[Yang, Wei]的文章
必应学术
必应学术中相似的文章
[Wu, Jin-yu]的文章
[Chen, Min-hua]的文章
[Yang, Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。