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Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task
Li Qiang1; Yang Wei-chuan1; Wang Ya-rong1; Huang Yu-fang2; Li Wei1; Zhu Jia1; Zhang Yi3; Zhao Li-yan4; Qin Wei3; Yuan Kai3; von Deneen, Karen M.3; Wang Wei1; Tian Jie1,3
关键词heroin craving resting-state posterior cingulate cortex functional magnetic resonance imaging
刊名CHINESE MEDICAL JOURNAL
2013-02-20
DOI10.3760/cma.j.issn.0366-6999.20120960
126期:4页:734-739
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]COCAINE-SEEKING ; DORSAL STRIATUM ; SMOKING CUES ; CONNECTIVITY ; BRAIN ; FMRI ; PERSISTENCE ; ACTIVATION ; WITHDRAWAL ; RECEPTORS
英文摘要

Background Previous animal and neuroimaging studies have demonstrated that brain function in heroin addicted users is impaired. However, the posterior cingulate cortex (PCC) has not received much attention. The purpose of this study was to investigate whether chronic heroin use is associated with craving-related changes in the functional connectivity of the PCC of heroin addicted users.

Methods Fourteen male adult chronic heroin users and fifteen age and gender-matched healthy subjects participated in the present study. The participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and a cue-induced craving task fMRI scan. The activated PCC was identified in the cue-induced craving task by means of a group contrast test. Functional connectivity was analyzed based on resting-state fMRI data in order to determine the correlation between brain regions. The relationship between the connectivity of specific regions and heroin dependence was investigated.

Results The activation of PCC, bilateral anterior cingulate cortex, caudate, putamen, precuneus, and thalamus was significant in the heroin group compared to the healthy group in the cue-induced craving task. The detectable functional connectivity of the heroin users was stronger between the PCC and bilateral insula, bilateral dorsal striatum, right inferior parietal lobule (IPL) and right supramarginal gyrus (P <0.001) compared to that of the healthy subjects in the resting-state data analysis. The strength of the functional connectivity, both for the PCC-insula (r=0.60, P <0.05) and for PCC-striatum (r=0.58, P <0.05), was positively correlated with the duration of heroin use.

Conclusion The altered functional connectivity patterns in the PCC-insula and PCC-striatum areas may be regarded as bionnarkers of brain damage severity in chronic heroin users.

语种英语
WOS记录号WOS:000319793800024
项目编号30870685 ; 81071142 ; 81071143 ; 81201081 ; 2008K12-02 ; 2009K01-65 ; 2010K16-03-01 ; 2010K16-03-02
资助机构National Natural Science Foundation of China ; Development Project of Science and Technology of Shaanxi Province
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66235
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.422 Mil Hosp, Dept Radiol, Zhanjiang 524000, Guangdong, Peoples R China
2.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
3.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
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Li Qiang,Yang Wei-chuan,Wang Ya-rong,et al. Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task[J]. CHINESE MEDICAL JOURNAL,2013,126(4):734-739.
APA Li Qiang.,Yang Wei-chuan.,Wang Ya-rong.,Huang Yu-fang.,Li Wei.,...&Tian Jie.(2013).Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task.CHINESE MEDICAL JOURNAL,126(4),734-739.
MLA Li Qiang,et al."Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task".CHINESE MEDICAL JOURNAL 126.4(2013):734-739.
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