北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Astrocyte and Neuron Intone Through Glutamate
作者: Yang, Chun Zhang1,2,3,4; Zhao, Rui1,2,3,4; Dong, Yan1,2,3,4; Chen, Xiao Qian5; Yu, Albert Cheung Hoi1,2,3,4
关键词: Glutamate ; Astrocyte ; Tripartite synapse ; Neuronal-astrocytic communication ; Swelling
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-12-01
DOI: 10.1007/s11064-008-9758-x
卷: 33, 期:12, 页:2480-2486
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: TYROSINE PROTEIN-KINASE ; LONG-TERM POTENTIATION ; GROWTH-FACTOR ; C-14-LABELED GLUTAMATE ; GLIAL LOCALIZATIONS ; GLUCOSE-UTILIZATION ; AEROBIC GLYCOLYSIS ; HIPPOCAMPAL SLICE ; ENERGY-METABOLISM ; SYNAPTIC ACTIVITY
英文摘要:

The unexpected finding of astrocytes to release glutamate as gliotransmitter challenges the traditional concepts on astrocyte being "passive′′ in CNS communications. Glutamate is the major excitatory transmitter in transferring information between neurons, but is now also known to activate astrocyte through transporters and receptors. Together with the sensitive swelling response, astrocytes could respond directly to glutamate and neuronal activity. Other new functions of astrocytes include modulation of synaptic plasticity and cerebral blood flow (CBF). The classic glutamate deplenishment through glutamine synthesis and CO2 production does not account for the total glutamate internalized into astrocytes. This leads us to speculate there are many hidden functions of glutamate in neurons and astrocytes waiting to be discovered. In this review, we attempted to reexamine some of these new and older functions of glutamate and to reevaluate the roles of glutamate intoning these two cell types.

语种: 英语
所属项目编号: 2006AA02Z452 ; 30270426 ; 30470543 ; 7032026 ; 7051004
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing National Natural Science Foundation of China
WOS记录号: WOS:000260961400011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66241
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Astrocyte and Neuron Intone Through Glutamate.pdf(196KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Peking Univ, Minist Publ Hlth, Key Lab Neurosci, Beijing 100083, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Minist Educ, Dept Pathophysiol,Key Lab Neurol Dis, Wuhan 430030, Hubei, Peoples R China

Recommended Citation:
Yang, Chun Zhang,Zhao, Rui,Dong, Yan,et al. Astrocyte and Neuron Intone Through Glutamate[J]. NEUROCHEMICAL RESEARCH,2008,33(12):2480-2486.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Chun Zhang]'s Articles
[Zhao, Rui]'s Articles
[Dong, Yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Chun Zhang]‘s Articles
[Zhao, Rui]‘s Articles
[Dong, Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace