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学科主题基础医学
Astrocyte and Neuron Intone Through Glutamate
Yang, Chun Zhang1,2,3,4; Zhao, Rui1,2,3,4; Dong, Yan1,2,3,4; Chen, Xiao Qian5; Yu, Albert Cheung Hoi1,2,3,4
关键词Glutamate Astrocyte Tripartite Synapse Neuronal-astrocytic Communication Swelling
刊名NEUROCHEMICAL RESEARCH
2008-12-01
DOI10.1007/s11064-008-9758-x
33期:12页:2480-2486
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]TYROSINE PROTEIN-KINASE ; LONG-TERM POTENTIATION ; GROWTH-FACTOR ; C-14-LABELED GLUTAMATE ; GLIAL LOCALIZATIONS ; GLUCOSE-UTILIZATION ; AEROBIC GLYCOLYSIS ; HIPPOCAMPAL SLICE ; ENERGY-METABOLISM ; SYNAPTIC ACTIVITY
英文摘要

The unexpected finding of astrocytes to release glutamate as gliotransmitter challenges the traditional concepts on astrocyte being "passive′′ in CNS communications. Glutamate is the major excitatory transmitter in transferring information between neurons, but is now also known to activate astrocyte through transporters and receptors. Together with the sensitive swelling response, astrocytes could respond directly to glutamate and neuronal activity. Other new functions of astrocytes include modulation of synaptic plasticity and cerebral blood flow (CBF). The classic glutamate deplenishment through glutamine synthesis and CO2 production does not account for the total glutamate internalized into astrocytes. This leads us to speculate there are many hidden functions of glutamate in neurons and astrocytes waiting to be discovered. In this review, we attempted to reexamine some of these new and older functions of glutamate and to reevaluate the roles of glutamate intoning these two cell types.

语种英语
WOS记录号WOS:000260961400011
项目编号2006AA02Z452 ; 30270426 ; 30470543 ; 7032026 ; 7051004
资助机构National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66241
专题北京大学基础医学院_神经生物学系
北京大学第一临床医学院_急诊科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Peking Univ, Minist Publ Hlth, Key Lab Neurosci, Beijing 100083, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Minist Educ, Dept Pathophysiol,Key Lab Neurol Dis, Wuhan 430030, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chun Zhang,Zhao, Rui,Dong, Yan,et al. Astrocyte and Neuron Intone Through Glutamate[J]. NEUROCHEMICAL RESEARCH,2008,33(12):2480-2486.
APA Yang, Chun Zhang,Zhao, Rui,Dong, Yan,Chen, Xiao Qian,&Yu, Albert Cheung Hoi.(2008).Astrocyte and Neuron Intone Through Glutamate.NEUROCHEMICAL RESEARCH,33(12),2480-2486.
MLA Yang, Chun Zhang,et al."Astrocyte and Neuron Intone Through Glutamate".NEUROCHEMICAL RESEARCH 33.12(2008):2480-2486.
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