北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
CCND1 G870A Polymorphism with Altered Cyclin D1 Transcripts Expression Is Associated with the Risk of Glioma in a Chinese Population
作者: Chen, Xiangmei1,2; Zhao, Tianshu3; Li, Li3; Xu, Chunhui1,2; Zhang, Xiaolei1,2; Tse, Vincent4; Zhang, Ting1,2; Liu, Xiaoqian3; Lu, Fengmin1,2
刊名: DNA AND CELL BIOLOGY
发表日期: 2012-06-01
DOI: 10.1089/dna.2011.1521
卷: 31, 期:6, 页:1107-1113
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; PROSTATE-CANCER ; SPLICE VARIANTS ; BREAST-CANCER ; SUSCEPTIBILITY ; TRANSFORMATION ; ESOPHAGEAL ; GENOTYPE ; ISOFORM
英文摘要:

A common polymorphism (G870A) in the exon 4/intron 4 boundary of CCND1 gene has been linked to an alternate transcript, cyclin D1b, which preferentially encodes a protein with an increased transforming capability compared with the full-length D1a. Therefore, the CCND1 G870A polymorphism may influence an individual′s susceptibility to the development of certain tumors. In the present study, we investigated the association of CCND1 G870A polymorphism with glioma cancer risk in a northern Chinese population. By polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis, CCND1 G870A genotyping was carried out among 170 glioma patients and 170 age, gender-matched healthy control subjects. The CCND1 870 A allele was more frequently observed in patients than in controls (0.57 vs. 0.48, p = 0.03), and an increased risk of glioma cancer was observed for the AA genotype compared with the GG and AG genotypes (odds ratio [OR] = 1.828; 95% confidence interval [CI]: 1.150-2.908, p = 0.01), particularly among female groups, or ages <= 45 groups (OR = 2.204, 95% CI: 1.220-3.981, p = 0.008). Significant associations were also observed between the AA genotype and glioma risk in the subgroups of World Health Organization (WHO) grade II gliomas and grade III gliomas. Further reverse transcriptase-polymerase chain reaction analysis (RT-PCR) also revealed a stronger positive correlation between the AA genotype and higher cyclin D1b expression among glioma patients either in the mean quantitative value, or the cyclin D1b/cyclin D1a ratio in the same tumor tissue (p = 0.008, p = 0.004, respectively). In conclusion, our data indicate that the CCND1 G870A polymorphism modulated oncogenic cyclin D1b expression in glioma tissues and may be associated with an increased risk of gliomas in Chinese population.

语种: 英语
所属项目编号: 30771099 ; 20100001110055
项目资助者: Natural Science foundation ; Doctoral Fund of Ministry of Education of China
WOS记录号: WOS:000305871900029
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66242
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
CCND1 G870A Polymorphism with Altered Cyclin D1 Transcripts Expression Is Associated with the Risk of Glioma in a Chinese Population.pdf(244KB)期刊论文出版稿限制开放View Download

作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 4, Harbin 150001, Heilongjiang Pr, Peoples R China
4.Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90024 USA

Recommended Citation:
Chen, Xiangmei,Zhao, Tianshu,Li, Li,et al. CCND1 G870A Polymorphism with Altered Cyclin D1 Transcripts Expression Is Associated with the Risk of Glioma in a Chinese Population[J]. DNA AND CELL BIOLOGY,2012,31(6):1107-1113.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Xiangmei]'s Articles
[Zhao, Tianshu]'s Articles
[Li, Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Xiangmei]‘s Articles
[Zhao, Tianshu]‘s Articles
[Li, Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: CCND1 G870A Polymorphism with Altered Cyclin D1 Transcripts Expression Is Associated with the Risk of Glioma in a Chinese Population.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace