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学科主题: 药物依赖
题名:
A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms
作者: Shi, Jie1; Xu, Guo-zhu1; Liu, Ting-ting1; Wang, Xi1; Shen, Li-yang1; Li, Jing2; Hao, Wei3; Chen, Hong-xian3; Li, Su-xia1; Lu, Lin1
关键词: Efficacy ; Jinniu capsule ; lofexidine ; opiate withdrawal syndrome ; safety
刊名: AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
发表日期: 2008
DOI: 10.1080/00952990802491563
卷: 34, 期:6, 页:792-800
收录类别: SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Substance Abuse
研究领域[WOS]: Psychology ; Substance Abuse
关键词[WOS]: MORPHINE-INDUCED HYPERACTIVITY ; OPIATE ADDICTION ; GINSENOSIDES ; ABUSE ; MICE
英文摘要:

Objective: Jinniu capsules, comprised of herbs and marine product extracts, are traditionally used in Chinese medicine. In this randomized multicenter clinical trial we evaluated the efficacy and safety of Jinniu capsules used to treat the symptoms of heroin withdrawal, as compared with lofexidine. Methods: Two hundred and twelve patients with heroin dependence were randomly assigned to the Jinniu capsule or lofexidine treatment groups during a 10-day double-blind clinical trial. The severity of their opiate withdrawal symptoms was measured daily for 10 days. Anxiety was measured on days 0, 5, and 10. Safety assessment of the drugs included measurement of vital signs and side effects, as well as laboratory tests. Results: Withdrawal symptom and anxiety scores decreased gradually over the treatment period, and no significant differences were found between two groups. No severe adverse events occurred during the treatment. Conclusion: Jinniu capsules may be an effective and safe agent in the management of opiate withdrawal.

语种: 英语
WOS记录号: WOS:000261018200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66248
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Sichuang Univ, W China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China
3.Xiangya Med Sch, Mental Hlth Inst, Changsha, Hunan, Peoples R China

Recommended Citation:
Shi, Jie,Xu, Guo-zhu,Liu, Ting-ting,et al. A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2008,34(6):792-800.
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