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学科主题药物依赖
A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms
Shi, Jie1; Xu, Guo-zhu1; Liu, Ting-ting1; Wang, Xi1; Shen, Li-yang1; Li, Jing2; Hao, Wei3; Chen, Hong-xian3; Li, Su-xia1; Lu, Lin1
关键词Efficacy Jinniu capsule lofexidine opiate withdrawal syndrome safety
刊名AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
2008
DOI10.1080/00952990802491563
34期:6页:792-800
收录类别SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Substance Abuse
研究领域[WOS]Psychology ; Substance Abuse
关键词[WOS]MORPHINE-INDUCED HYPERACTIVITY ; OPIATE ADDICTION ; GINSENOSIDES ; ABUSE ; MICE
英文摘要

Objective: Jinniu capsules, comprised of herbs and marine product extracts, are traditionally used in Chinese medicine. In this randomized multicenter clinical trial we evaluated the efficacy and safety of Jinniu capsules used to treat the symptoms of heroin withdrawal, as compared with lofexidine. Methods: Two hundred and twelve patients with heroin dependence were randomly assigned to the Jinniu capsule or lofexidine treatment groups during a 10-day double-blind clinical trial. The severity of their opiate withdrawal symptoms was measured daily for 10 days. Anxiety was measured on days 0, 5, and 10. Safety assessment of the drugs included measurement of vital signs and side effects, as well as laboratory tests. Results: Withdrawal symptom and anxiety scores decreased gradually over the treatment period, and no significant differences were found between two groups. No severe adverse events occurred during the treatment. Conclusion: Jinniu capsules may be an effective and safe agent in the management of opiate withdrawal.

语种英语
WOS记录号WOS:000261018200015
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66248
Collection北京大学第三临床医学院_总务处
北京大学医学部管理机构_医学部
中国药物依赖性研究所
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Sichuang Univ, W China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China
3.Xiangya Med Sch, Mental Hlth Inst, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Shi, Jie,Xu, Guo-zhu,Liu, Ting-ting,et al. A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2008,34(6):792-800.
APA Shi, Jie.,Xu, Guo-zhu.,Liu, Ting-ting.,Wang, Xi.,Shen, Li-yang.,...&Lu, Lin.(2008).A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,34(6),792-800.
MLA Shi, Jie,et al."A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 34.6(2008):792-800.
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