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学科主题: 临床医学
题名:
Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma
作者: Zhang, Xiaotian; Yashiro, Masakazu; Ohira, Masaichi; Ren, Jun; Hirakawa, Kosei
刊名: CANCER SCIENCE
发表日期: 2006-09-01
DOI: 10.1111/j.1349-7006.2006.00253.x
卷: 97, 期:9, 页:938-944
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR-BETA ; CANCER-CELL-LINES ; AGENT 5-AZA-2&prime ; -DEOXYCYTIDINE DECITABINE ; CHRONIC MYELOGENOUS LEUKEMIA ; TUMOR-SUPPRESSOR GENE ; PHASE-II ; PROMOTER HYPERMETHYLATION ; PROSTATE-CANCER ; FOLINIC ACID ; TGF-BETA
英文摘要:

Epigenetic alterations of DNA methylation play an important role in the regulation of gene expression associated with chemosensitivity of gastric carcinomas. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of DNA methyltransferase inhibitor, 5-aza-CdR, on the chemosensitivity of five anticancer drugs was investigated. Human gastric cancer cell lines, OCUM-2M and MKN-74, and five anticancer drugs, 5-FU, PTX, OXA, SN38, and GEM, were used. In both gastric cancer cell lines, a synergistic antiproliferative effect by a combination of 5-aza-CdR at 5 mu M was found in SN38 and GEM. 5-Aza-CdR at 5 mu M increased apoptosis induced by SN38 and GEM in both cell lines. 5-Aza-CdR increases the expression of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes in both OCUM-2M and MKN-74 cells, but not that of hMLH1, p16, MGMT, E-cadherin, and p53 genes. These findings suggest that 5-aza-CdR is a promising chemotherapeutical agent for gastric carcinomas, in combination with the anticancer drugs SN38 and GEM, in apoptosis signaling. The upregulation of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes by 5-aza-CdR might be associated with the synergistic effect.

语种: 英语
WOS记录号: WOS:000239454000021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66251
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Med Oncol, Beijing, Peoples R China
2.Osaka City Univ, Sch Med, Dept Surg Oncol, Obeno Ku, Osaka 5458585, Japan

Recommended Citation:
Zhang, Xiaotian,Yashiro, Masakazu,Ohira, Masaichi,et al. Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma[J]. CANCER SCIENCE,2006,97(9):938-944.
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