IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma
Zhang, Xiaotian; Yashiro, Masakazu; Ohira, Masaichi; Ren, Jun; Hirakawa, Kosei
刊名CANCER SCIENCE
2006-09-01
DOI10.1111/j.1349-7006.2006.00253.x
97期:9页:938-944
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR-BETA ; CANCER-CELL-LINES ; AGENT 5-AZA-2&prime ; -DEOXYCYTIDINE DECITABINE ; CHRONIC MYELOGENOUS LEUKEMIA ; TUMOR-SUPPRESSOR GENE ; PHASE-II ; PROMOTER HYPERMETHYLATION ; PROSTATE-CANCER ; FOLINIC ACID ; TGF-BETA
英文摘要

Epigenetic alterations of DNA methylation play an important role in the regulation of gene expression associated with chemosensitivity of gastric carcinomas. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of DNA methyltransferase inhibitor, 5-aza-CdR, on the chemosensitivity of five anticancer drugs was investigated. Human gastric cancer cell lines, OCUM-2M and MKN-74, and five anticancer drugs, 5-FU, PTX, OXA, SN38, and GEM, were used. In both gastric cancer cell lines, a synergistic antiproliferative effect by a combination of 5-aza-CdR at 5 mu M was found in SN38 and GEM. 5-Aza-CdR at 5 mu M increased apoptosis induced by SN38 and GEM in both cell lines. 5-Aza-CdR increases the expression of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes in both OCUM-2M and MKN-74 cells, but not that of hMLH1, p16, MGMT, E-cadherin, and p53 genes. These findings suggest that 5-aza-CdR is a promising chemotherapeutical agent for gastric carcinomas, in combination with the anticancer drugs SN38 and GEM, in apoptosis signaling. The upregulation of DAPK-2 and DAPK-3, RASSF1, and THBS1 genes by 5-aza-CdR might be associated with the synergistic effect.

语种英语
WOS记录号WOS:000239454000021
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66251
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Med Oncol, Beijing, Peoples R China
2.Osaka City Univ, Sch Med, Dept Surg Oncol, Obeno Ku, Osaka 5458585, Japan
推荐引用方式
GB/T 7714
Zhang, Xiaotian,Yashiro, Masakazu,Ohira, Masaichi,et al. Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma[J]. CANCER SCIENCE,2006,97(9):938-944.
APA Zhang, Xiaotian,Yashiro, Masakazu,Ohira, Masaichi,Ren, Jun,&Hirakawa, Kosei.(2006).Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma.CANCER SCIENCE,97(9),938-944.
MLA Zhang, Xiaotian,et al."Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma".CANCER SCIENCE 97.9(2006):938-944.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ohira, Masaichi]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ohira, Masaichi]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ohira, Masaichi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。