北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population
作者: Zhou, Cheng-Jiang1; Zhang, Liu-Wei2; Gao, Fang1; Zhang, Bin1; Wang, Ying1; Chen, Da-Fang2; Jia, Yan-Bin1
关键词: Non-cardia gastric cancer ; MUC5AC ; tagSNP ; risk ; Baotou ; China
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.10.4207
卷: 15, 期:10, 页:4207-4210
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HELICOBACTER-PYLORI ; EXPRESSION ; MUC1 ; ADENOCARCINOMA ; CARCINOMA ; STOMACH ; POLYMORPHISMS ; ESOPHAGEAL ; INFECTION ; ANTIBODY
英文摘要:

Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95% CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95% CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

语种: 英语
所属项目编号: 30960169 ; 81250024 ; 2011MS1103 ; 20110501 ; NJzy08138 ; 2008-34
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Inner Mongolia ; Inner Mongolian Committee of Science and Technology, China ; Scientific Research Foundation of the Higher Education Institutions of Inner Mongolian Autonomous Region, China ; Foundation of Medicine and Health of Baotou, China
WOS记录号: WOS:000338634400017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66254
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Baotou Med Coll, Sch Basic Med, Baotou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,et al. Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(10):4207-4210.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Cheng-Jiang]'s Articles
[Zhang, Liu-Wei]'s Articles
[Gao, Fang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Cheng-Jiang]‘s Articles
[Zhang, Liu-Wei]‘s Articles
[Gao, Fang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace