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Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population
Zhou, Cheng-Jiang1; Zhang, Liu-Wei2; Gao, Fang1; Zhang, Bin1; Wang, Ying1; Chen, Da-Fang2; Jia, Yan-Bin1
关键词Non-cardia gastric cancer MUC5AC tagSNP risk Baotou China
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2014
DOI10.7314/APJCP.2014.15.10.4207
15期:10页:4207-4210
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HELICOBACTER-PYLORI ; EXPRESSION ; MUC1 ; ADENOCARCINOMA ; CARCINOMA ; STOMACH ; POLYMORPHISMS ; ESOPHAGEAL ; INFECTION ; ANTIBODY
英文摘要

Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95% CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95% CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

语种英语
WOS记录号WOS:000338634400017
项目编号30960169 ; 81250024 ; 2011MS1103 ; 20110501 ; NJzy08138 ; 2008-34
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Inner Mongolia ; Inner Mongolian Committee of Science and Technology, China ; Scientific Research Foundation of the Higher Education Institutions of Inner Mongolian Autonomous Region, China ; Foundation of Medicine and Health of Baotou, China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66254
专题北京大学公共卫生学院
北京大学基础医学院
作者单位1.Baotou Med Coll, Sch Basic Med, Baotou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
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GB/T 7714
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,et al. Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(10):4207-4210.
APA Zhou, Cheng-Jiang.,Zhang, Liu-Wei.,Gao, Fang.,Zhang, Bin.,Wang, Ying.,...&Jia, Yan-Bin.(2014).Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(10),4207-4210.
MLA Zhou, Cheng-Jiang,et al."Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.10(2014):4207-4210.
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