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学科主题: 公共卫生
题名:
Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population
作者: Zhou, Cheng-Jiang1; Zhang, Liu-Wei2; Gao, Fang1; Zhang, Bin1; Wang, Ying1; Chen, Da-Fang2; Jia, Yan-Bin1
关键词: Non-cardia gastric cancer ; MUC5AC ; tagSNP ; risk ; Baotou ; China
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.10.4207
卷: 15, 期:10, 页:4207-4210
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HELICOBACTER-PYLORI ; EXPRESSION ; MUC1 ; ADENOCARCINOMA ; CARCINOMA ; STOMACH ; POLYMORPHISMS ; ESOPHAGEAL ; INFECTION ; ANTIBODY
英文摘要:

Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95% CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95% CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

语种: 英语
所属项目编号: 30960169 ; 81250024 ; 2011MS1103 ; 20110501 ; NJzy08138 ; 2008-34
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Inner Mongolia ; Inner Mongolian Committee of Science and Technology, China ; Scientific Research Foundation of the Higher Education Institutions of Inner Mongolian Autonomous Region, China ; Foundation of Medicine and Health of Baotou, China
WOS记录号: WOS:000338634400017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66254
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Baotou Med Coll, Sch Basic Med, Baotou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,et al. Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(10):4207-4210.
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