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学科主题: 临床医学
题名:
Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway
作者: Zhang, Xiao-Hui1; Feng, Ru2; Lv, Meng1; Jiang, Qian1; Zhu, Hong-Hu1; Qing, Ya-Zhen1; Bao, Jia-Ling3,4; Huang, Xiao-Jun1; Zheng, X. Long3,4
关键词: Arsenic trioxide ; WSU-CLL ; Apoptosis ; Survivin ; P53 and CLL
刊名: LEUKEMIA RESEARCH
发表日期: 2013-12-01
DOI: 10.1016/j.leukres.2013.09.019
卷: 37, 期:12, 页:1719-1725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: LUNG-CARCINOMA CELLS ; WILD-TYPE P53 ; DNA-SYNTHESIS ; UP-REGULATION ; CLL CELLS ; SUPPRESSION ; REPRESSION ; EXPRESSION ; INDUCTION ; GROWTH
英文摘要:

Arsenic trioxide (As2O3) can induce apoptosis in many tumors. However, the associated mechanisms are not clearly understood. We found that As2O3 significantly inhibited the proliferation of WSU-CLL cells and induced apoptosis in dose- and time-dependent manners. WSU-CLL cells treated with 2 mu M As2O3 showed survivin down-regulation and p53 up-regulation. Survivin siRNA combined with As2O3 further inhibited the proliferation of WSU-CLL cells. p53 inhibition by siRNA prevented the down-regulation of survivin by As2O3 and prevented the As2O3-induced cytotoxicity of WSU-CLL cells. These results suggest that As2O3 may be of therapeutic value for chronic lymphocytic leukemia. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81270643 ; 81070449 ; 2012BAI38B03 ; 7112139
项目资助者: National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing
WOS记录号: WOS:000327539700021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66257
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Minist Hlth, Beijing Hosp, Dept Hematol, Beijing 100730, Peoples R China
2.Univ Penn, Philadelphia, PA 19104 USA
3.Peking Univ Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
4.Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Recommended Citation:
Zhang, Xiao-Hui,Feng, Ru,Lv, Meng,et al. Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway[J]. LEUKEMIA RESEARCH,2013,37(12):1719-1725.
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