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Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway
Zhang, Xiao-Hui1; Feng, Ru2; Lv, Meng1; Jiang, Qian1; Zhu, Hong-Hu1; Qing, Ya-Zhen1; Bao, Jia-Ling3,4; Huang, Xiao-Jun1; Zheng, X. Long3,4
关键词Arsenic trioxide WSU-CLL Apoptosis Survivin P53 and CLL
刊名LEUKEMIA RESEARCH
2013-12-01
DOI10.1016/j.leukres.2013.09.019
37期:12页:1719-1725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]LUNG-CARCINOMA CELLS ; WILD-TYPE P53 ; DNA-SYNTHESIS ; UP-REGULATION ; CLL CELLS ; SUPPRESSION ; REPRESSION ; EXPRESSION ; INDUCTION ; GROWTH
英文摘要

Arsenic trioxide (As2O3) can induce apoptosis in many tumors. However, the associated mechanisms are not clearly understood. We found that As2O3 significantly inhibited the proliferation of WSU-CLL cells and induced apoptosis in dose- and time-dependent manners. WSU-CLL cells treated with 2 mu M As2O3 showed survivin down-regulation and p53 up-regulation. Survivin siRNA combined with As2O3 further inhibited the proliferation of WSU-CLL cells. p53 inhibition by siRNA prevented the down-regulation of survivin by As2O3 and prevented the As2O3-induced cytotoxicity of WSU-CLL cells. These results suggest that As2O3 may be of therapeutic value for chronic lymphocytic leukemia. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000327539700021
项目编号81270643 ; 81070449 ; 2012BAI38B03 ; 7112139
资助机构National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66257
专题北京大学第二临床医学院
作者单位1.Minist Hlth, Beijing Hosp, Dept Hematol, Beijing 100730, Peoples R China
2.Univ Penn, Philadelphia, PA 19104 USA
3.Peking Univ Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
4.Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
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Zhang, Xiao-Hui,Feng, Ru,Lv, Meng,et al. Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway[J]. LEUKEMIA RESEARCH,2013,37(12):1719-1725.
APA Zhang, Xiao-Hui.,Feng, Ru.,Lv, Meng.,Jiang, Qian.,Zhu, Hong-Hu.,...&Zheng, X. Long.(2013).Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.LEUKEMIA RESEARCH,37(12),1719-1725.
MLA Zhang, Xiao-Hui,et al."Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway".LEUKEMIA RESEARCH 37.12(2013):1719-1725.
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