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学科主题: 临床医学
题名:
Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents
作者: Shu, CY; Gan, LH; Wang, CR; Pei, XL; Han, HB
关键词: fullerene ; magnetic properties ; X-ray photoelectron spectroscopy ; electronic structure ; aggregation
刊名: CARBON
发表日期: 2006-03-01
DOI: 10.1016/j.carbon.2005.08.016
卷: 44, 期:3, 页:496-500
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: NANOSCALE AGGREGATION ; AQUEOUS-SOLUTION ; IN-VIVO ; FULLERENE ; DERIVATIVES ; INHIBITION ; RELAXIVITY ; COMPLEXES ; BEHAVIOR
英文摘要:

Water-soluble amino acid derivatives of gadolinium (Gd) endohedral metallofullerenes (AAD-EMFs), Gd@C82Om(OH)(n)(NHCH2CH2COOH)(l) (m approximate to 6, n approximate to 16 and l approximate to 8) are synthesized by a direct reaction of the pure endohedral metallofullerene Gd@C-82 with an excess of alkaline solution of beta-alanine. The structure of the AAD-EMFs is characterized by FTIR, XPS and laser-desorption time-of-flight (LD-TOF) mass spectrometries. Water proton relaxivity analysis indicates that the longitudinal relaxivity R-1 (the effect on 1/T-1, 9.1 mM(-1) s(-1)) of AAD-EMFs is higher than that of the commercial MRI contrast agent, Magnevist (gadolinium-diethylenetriaminepentaacetic acid, Gd-DTPA, 5.6 mM(-1) s(-1)). The MRI phantom studies are performed to confirm the high efficiency of this sample as MRI contrast agents. (C) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000234186700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66266
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Peking Univ, Hosp 3, Dept Irradiat, Beijing 100083, Peoples R China

Recommended Citation:
Shu, CY,Gan, LH,Wang, CR,et al. Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents[J]. CARBON,2006,44(3):496-500.
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