IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta 1 in prostate tissue of spontaneously hypertensive rats
Yu, Wei; Zhao, Ya-Yuan; Zhang, Zhi-Wen; Guo, Ying-Lu; Jin, Jie
关键词prostate rats apoptosis TGF beta 1 type 1 angiotensin receptor blockers rat model
刊名BJU INTERNATIONAL
2007-11-01
DOI10.1111/j.1464-410X.2007.07150.x
100期:5页:1161-1165
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GROWTH-FACTOR-BETA ; RENIN-ANGIOTENSIN SYSTEM ; II RECEPTOR BLOCKER ; ANTIPROLIFERATIVE ACTIVITY ; CELL-PROLIFERATION ; CANCER CELLS ; BENIGN ; HYPERPLASIA ; TYPE-1
英文摘要

To assess whether angiotensin II (Ang II), important in hypertension and highly expressed in benign prostatic hyperplasia (BPH), is involved in prostate growth, by analysing changes in the histological composition, tissue apoptotic status and level of transforming growth factor-beta 1 (TGF beta 1) induced by an Ang II type 1 receptor blocker, losartan, in the prostates of spontaneously hypertensive (SH) rats.

We assessed four groups of six rats each: normotensive Wistar-Kyoto counterparts of SH rats; untreated SH rats; SH rats given low-dose losartan ( 10 mg/kg/day for 10 weeks); and SH given high-dose losartan ( 30 mg/kg/ day for 10 weeks). We evaluated the histological composition and expression of TGF beta 1 and apoptosis-related proteins, i.e. Bax and the 116-kDa poly ( adenosine diphosphate-ribose) polymerase ( PARP), by Western blotting in the rat prostate ventral lobes.

Compared with Wistar-Kyoto rats, untreated SH rats had a significantly increased epithelium component in the prostate ( P < 0.01), but with losartan treatment, SH rats showed less of the epithelium component than untreated rats ( P < 0.01 for both low-and high-dose losartan). Western-blot analysis showed a significantly increased level of Bax in high-dose losartan-treated rats ( P < 0.01). The expression of 116 kDa PARP was also decreased in these rats ( P < 0.01), which suggests increased caspase-3 activity. In addition, TGF beta 1 levels were significantly elevated in high-dose losartan-treated rats ( P < 0.01).

These results show that losartan can induce apoptosis of prostate epithelium and increase the TGF beta 1 expression in SH rats, suggesting that Ang II stimulation might be involved in the pathogenesis of BPH, which might correlate with the regulation of TGF beta 1 expression.

语种英语
WOS记录号WOS:000249953400036
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66272
Collection北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Peking Univ First Hosp, Dept Urol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Yu, Wei,Zhao, Ya-Yuan,Zhang, Zhi-Wen,et al. Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta 1 in prostate tissue of spontaneously hypertensive rats[J]. BJU INTERNATIONAL,2007,100(5):1161-1165.
APA Yu, Wei,Zhao, Ya-Yuan,Zhang, Zhi-Wen,Guo, Ying-Lu,&Jin, Jie.(2007).Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta 1 in prostate tissue of spontaneously hypertensive rats.BJU INTERNATIONAL,100(5),1161-1165.
MLA Yu, Wei,et al."Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta 1 in prostate tissue of spontaneously hypertensive rats".BJU INTERNATIONAL 100.5(2007):1161-1165.
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