IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Myeloperoxidase influences the complement regulatory function of modified C-reactive protein
Xu, Peng-cheng1,2; Li, Zhi-ying1; Yang, Xiao-wei1; Zhao, Ming-hui1; Chen, Min1
关键词vasculitis Myeloperoxidase complement anti-neutrophil cytoplasmic Ab C-reactive protein
刊名INNATE IMMUNITY
2014-05-01
DOI10.1177/1753425913508164
20期:4页:440-448
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Immunology ; Medicine, Research & Experimental ; Microbiology
资助者Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund ; Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund
研究领域[WOS]Biochemistry & Molecular Biology ; Immunology ; Research & Experimental Medicine ; Microbiology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; SMALL-VESSEL VASCULITIS ; MICROSCOPIC POLYANGIITIS ; HUMAN NEUTROPHILS ; ACTIVATION ; DISEASE ; BINDING ; CRP ; GRANULOMATOSIS ; INFLAMMATION
英文摘要

In patients with active anti-neutrophil cytoplasmic Ab (ANCA)-associated vasculitis (AAV), there are high levels of circulating C-reactive protein (CRP), which can inhibit the alternative complement pathway by binding factor H and triggering the classical complement pathway by binding C1q. However, the alternative, not the classical, complement pathway has been proven to play an important role in AAV. We found that both purified myeloperoxidase (MPO) and MPO released from ANCA-stimulated neutrophils could bind modified CRP (mCRP), but not pentameric CRP. Furthermore, MPO could block the binding between mCRP and factor H, as well as the binding between mCRP and C1q. Binding with mCRP did not influence the enzymatic activity of MPO. Binding with mCRP also did not influence the binding between MPO and its physical inhibitor, ceruloplasmin, as well as the binding between MPO and MPO-ANCA. The results indicated that MPO might be a complement regulator and inhibit the negative regulatory effect of CRP on the alternative complement pathway.

语种英语
所属项目编号2012CB517702 ; 20120001110018 ; 81370829 ; 81021004
资助者Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund ; Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund
WOS记录号WOS:000334548000010
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66273
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Key Lab Renal Dis, Minist Hlth China,Peking Tsinghua Ctr Life Sci, Div Renal,Dept Med,Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Dept Nephrol, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Xu, Peng-cheng,Li, Zhi-ying,Yang, Xiao-wei,et al. Myeloperoxidase influences the complement regulatory function of modified C-reactive protein[J]. INNATE IMMUNITY,2014,20(4):440-448.
APA Xu, Peng-cheng,Li, Zhi-ying,Yang, Xiao-wei,Zhao, Ming-hui,&Chen, Min.(2014).Myeloperoxidase influences the complement regulatory function of modified C-reactive protein.INNATE IMMUNITY,20(4),440-448.
MLA Xu, Peng-cheng,et al."Myeloperoxidase influences the complement regulatory function of modified C-reactive protein".INNATE IMMUNITY 20.4(2014):440-448.
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