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学科主题: 精神卫生
题名:
Associations of ATF4 gene polymorphisms with schizophrenia in male patients
作者: Qu, Mei; Tang, Fulei; Wang, Lifang; Yan, Hao; Han, Yonghua; Yan, Jun; Yue, Weihua; Zhang, Dai
关键词: activating transcription factor 4 (ATF4) ; haplotype ; genetic association
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2008-09-05
DOI: 10.1002/ajmg.b.30675
卷: 147B, 期:6, 页:732-736
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: ACTIVATING TRANSCRIPTION FACTOR-4 ; BIPOLAR DISORDER ; SYNAPTIC PLASTICITY ; DISC1 ; RECEPTOR ; LINKAGE ; MEMORY ; INTERACTS ; PROTEINS ; RISK
英文摘要:

Activating transcription factor 4 (ATF4) is considered as a positional candidate gene for schizophrenia due to its location at chromosome 22q13, a region linked to schizophrenia. Furthermore, as protein interaction partner of ATF4, disrupted in schizophrenia 1 (DISC1) and its signal pathway implicated in the pathophysiology of schizophrenia have been widely supported by a number of genetic and neurobiological studies. Our aim was to investigate whether ATF4 is associated with schizophrenia in case-control samples of Han Chinese subjects consisting of 352 schizophrenia patients and 357 healthy controls. We detected 18 single nucleotide polyrnorphisms (SNPs) in ATF4 locus, two of which were analyzed, including one insertion at the putative core promoter region (rs17001266, -/C) and one nonsynonymous variant in exon 1 (rs4894, C/A, Pro22Gln). Allele distributions of two SNPs showed significant associations with schizophrenia in male subjects (respectively, rs17001266: P = 0.021, OR = 1.58, 95% CI=1.07-2.33; rs4894: P=0.004, OR=1.78, 95% CI=1.19-2.67), but not in female subjects as well as the entire population. Two haplotypes CC and -A constructed of rs17001266-rs4894 also revealed significant associations with schizophrenia in male group (global P=0.0097). These findings support that ATF4 gene may be involved in susceptibility to schizophrenia with sex-dependent effect in the Chinese Han population and suggest that further functional assays are needed to verify their relevance to the pathogenesis of schizophrenia. (c) 2007 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 30530290 ; 30400149 ; 2007CB512301 ; 2006AA02Z195 ; 2007AA02Z423
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program of China
WOS记录号: WOS:000259050100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66277
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Qu, Mei,Tang, Fulei,Wang, Lifang,et al. Associations of ATF4 gene polymorphisms with schizophrenia in male patients[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2008,147B(6):732-736.
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