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Associations of ATF4 gene polymorphisms with schizophrenia in male patients
Qu, Mei; Tang, Fulei; Wang, Lifang; Yan, Hao; Han, Yonghua; Yan, Jun; Yue, Weihua; Zhang, Dai
关键词activating transcription factor 4 (ATF4) haplotype genetic association
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2008-09-05
DOI10.1002/ajmg.b.30675
147B期:6页:732-736
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]ACTIVATING TRANSCRIPTION FACTOR-4 ; BIPOLAR DISORDER ; SYNAPTIC PLASTICITY ; DISC1 ; RECEPTOR ; LINKAGE ; MEMORY ; INTERACTS ; PROTEINS ; RISK
英文摘要

Activating transcription factor 4 (ATF4) is considered as a positional candidate gene for schizophrenia due to its location at chromosome 22q13, a region linked to schizophrenia. Furthermore, as protein interaction partner of ATF4, disrupted in schizophrenia 1 (DISC1) and its signal pathway implicated in the pathophysiology of schizophrenia have been widely supported by a number of genetic and neurobiological studies. Our aim was to investigate whether ATF4 is associated with schizophrenia in case-control samples of Han Chinese subjects consisting of 352 schizophrenia patients and 357 healthy controls. We detected 18 single nucleotide polyrnorphisms (SNPs) in ATF4 locus, two of which were analyzed, including one insertion at the putative core promoter region (rs17001266, -/C) and one nonsynonymous variant in exon 1 (rs4894, C/A, Pro22Gln). Allele distributions of two SNPs showed significant associations with schizophrenia in male subjects (respectively, rs17001266: P = 0.021, OR = 1.58, 95% CI=1.07-2.33; rs4894: P=0.004, OR=1.78, 95% CI=1.19-2.67), but not in female subjects as well as the entire population. Two haplotypes CC and -A constructed of rs17001266-rs4894 also revealed significant associations with schizophrenia in male group (global P=0.0097). These findings support that ATF4 gene may be involved in susceptibility to schizophrenia with sex-dependent effect in the Chinese Han population and suggest that further functional assays are needed to verify their relevance to the pathogenesis of schizophrenia. (c) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000259050100010
项目编号30530290 ; 30400149 ; 2007CB512301 ; 2006AA02Z195 ; 2007AA02Z423
资助机构National Natural Science Foundation of China ; Major State Basic Research Development Program of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66277
专题北京大学精神卫生研究所
北京大学公共卫生学院_公共卫生学院
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Qu, Mei,Tang, Fulei,Wang, Lifang,et al. Associations of ATF4 gene polymorphisms with schizophrenia in male patients[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2008,147B(6):732-736.
APA Qu, Mei.,Tang, Fulei.,Wang, Lifang.,Yan, Hao.,Han, Yonghua.,...&Zhang, Dai.(2008).Associations of ATF4 gene polymorphisms with schizophrenia in male patients.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,147B(6),732-736.
MLA Qu, Mei,et al."Associations of ATF4 gene polymorphisms with schizophrenia in male patients".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 147B.6(2008):732-736.
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