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Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs
Wang, Chenhong1,2; Zhang, Kuo3; Wang, Heran1,2; Xu, Shanshan1; Han, Charles C.1
关键词Degradation PLGA scaffolds Implantation
刊名POLYMER
2015-03-20
DOI10.1016/j.polymer.2015.02.001
61页:174-182
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]PLGA MICROSPHERES ; DRUG-DELIVERY ; EXPERIMENTAL-MODEL ; MORPHOLOGY CHANGES ; MICROCLIMATE PH ; END SCISSION ; DEGRADATION ; HYDROLYSIS ; MECHANISMS ; COPOLYMERS
英文摘要

Study of the degradation behavior of implants is of crucial importance in biomedical fields before practical applications. In this study, degradability of poly (DL-lactic-co-glycolic acid) (PDLGA)/poly (DL-lactide)-block-poly (ethylene glycol) (PDLA-b-PEG) scaffolds was evaluated both in vitro and in vivo. In vitro degradation of fibrous scaffolds showed that highly porous structure facilitated the diffusion of soluble degraded products out of the scaffolds. The electrospun scaffolds could maintain the structural integrity and the fibrous morphology in vitro for 8 weeks and during the wound healing process in vivo. When implanted in vivo, the scaffolds had good biocompatibility and degraded faster than in vitro. Long term study of degradation in rats showed that the scaffolds were totally degraded and absorbed. Faster degradation in pigs than in rats might due to the surgical condition and difference of physiological environment between rats and pigs, such as wound area, hemorrhage, the local motion and inflammatory reaction. The interaction between the scaffolds and the surrounding tissues would also influence the degradation of the implants. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000352118200021
项目编号51003110 ; KJCX2-YW-H19
资助机构National Nature Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66279
专题实验动物科学部
北京大学医学部管理机构_医学部
作者单位1.Chinese Acad Sci, Joint Lab Polymer Sci & Mat, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Chenhong,Zhang, Kuo,Wang, Heran,et al. Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs[J]. POLYMER,2015,61:174-182.
APA Wang, Chenhong,Zhang, Kuo,Wang, Heran,Xu, Shanshan,&Han, Charles C..(2015).Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs.POLYMER,61,174-182.
MLA Wang, Chenhong,et al."Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs".POLYMER 61(2015):174-182.
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