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学科主题: 实验动物
题名:
Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs
作者: Wang, Chenhong1,2; Zhang, Kuo3; Wang, Heran1,2; Xu, Shanshan1; Han, Charles C.1
关键词: Degradation ; PLGA scaffolds ; Implantation
刊名: POLYMER
发表日期: 2015-03-20
DOI: 10.1016/j.polymer.2015.02.001
卷: 61, 页:174-182
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
关键词[WOS]: PLGA MICROSPHERES ; DRUG-DELIVERY ; EXPERIMENTAL-MODEL ; MORPHOLOGY CHANGES ; MICROCLIMATE PH ; END SCISSION ; DEGRADATION ; HYDROLYSIS ; MECHANISMS ; COPOLYMERS
英文摘要:

Study of the degradation behavior of implants is of crucial importance in biomedical fields before practical applications. In this study, degradability of poly (DL-lactic-co-glycolic acid) (PDLGA)/poly (DL-lactide)-block-poly (ethylene glycol) (PDLA-b-PEG) scaffolds was evaluated both in vitro and in vivo. In vitro degradation of fibrous scaffolds showed that highly porous structure facilitated the diffusion of soluble degraded products out of the scaffolds. The electrospun scaffolds could maintain the structural integrity and the fibrous morphology in vitro for 8 weeks and during the wound healing process in vivo. When implanted in vivo, the scaffolds had good biocompatibility and degraded faster than in vitro. Long term study of degradation in rats showed that the scaffolds were totally degraded and absorbed. Faster degradation in pigs than in rats might due to the surgical condition and difference of physiological environment between rats and pigs, such as wound area, hemorrhage, the local motion and inflammatory reaction. The interaction between the scaffolds and the surrounding tissues would also influence the degradation of the implants. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 51003110 ; KJCX2-YW-H19
项目资助者: National Nature Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences
WOS记录号: WOS:000352118200021
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66279
Appears in Collections:实验动物科学部_期刊论文

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作者单位: 1.Chinese Acad Sci, Joint Lab Polymer Sci & Mat, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Chenhong,Zhang, Kuo,Wang, Heran,et al. Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs[J]. POLYMER,2015,61:174-182.
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