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学科主题: 临床医学
题名:
Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development
作者: Zhang, Chun-Hui1,2; Qian, Wei-Ping1; Qi, Shu-Tao2; Ge, Zhao-Jia2; Min, Ling-Jiang2,4; Zhu, Xiu-Lang2; Huang, Xin2; Liu, Jing-Ping1; Ouyang, Ying-Chun2; Hou, Yi2; Schatten, Heide3; Sun, Qing-Yuan2
关键词: Endoplasmic reticulum ; Maternal diabetes ; Oocyte maturation ; Early embryo
刊名: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
发表日期: 2013-04-19
DOI: 10.1186/1477-7827-11-31
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS ; UNFOLDED-PROTEIN RESPONSE ; MEIOTIC MATURATION ; STRUCTURAL-CHANGES ; EGG ACTIVATION ; CA2+ RELEASE ; FERTILIZATION ; LOCALIZATION ; ER ; REORGANIZATION
英文摘要:

Background: The adverse effects of maternal diabetes on oocyte maturation and embryo development have been reported.

Methods: In this study, we used time-lapse live cell imaging confocal microscopy to investigate the dynamic changes of ER and the effects of diabetes on the ER′s structural dynamics during oocyte maturation, fertilization and early embryo development.

Results: We report that the ER first became remodeled into a dense ring around the developing MI spindle, and then surrounded the spindle during migration to the cortex. ER reorganization during mouse early embryo development was characterized by striking localization around the pronuclei in the equatorial section, in addition to larger areas of fluorescence deeper within the cytoplasm. In contrast, in diabetic mice, the ER displayed a significantly higher percentage of homogeneous distribution patterns throughout the entire ooplasm during oocyte maturation and early embryo development. In addition, a higher frequency of large ER aggregations was detected in GV oocytes and two cell embryos from diabetic mice.

Conclusions: These results suggest that the diabetic condition adversely affects the ER distribution pattern during mouse oocyte maturation and early embryo development.

语种: 英语
所属项目编号: 81200438 ; 30930065
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000318085700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66284
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Med Ctr, Shenzhen Hosp, Dept Reprod Med, Shenzhen, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China
3.Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA
4.Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao 266109, Peoples R China

Recommended Citation:
Zhang, Chun-Hui,Qian, Wei-Ping,Qi, Shu-Tao,et al. Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2013,11.
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