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Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin
Duan, Cunxian1; Gao, Jian2; Zhang, Dianrui1; Jia, Lejiao1; Liu, Yue1; Zheng, Dandan1; Liu, Guangpu1; Tian, Xiaona1; Wang, Fengshan3; Zhang, Qiang4
刊名BIOMACROMOLECULES
2011-12-01
DOI10.1021/bm201270m
12期:12页:4335-4343
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Basic Research Program of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]HYDROPHILIC BLOCK-COPOLYMER ; TUMOR EXTRACELLULAR PH ; DRUG-DELIVERY ; IN-VITRO ; CANCER-THERAPY ; NANOPARTICLES ; CHITOSAN ; MICELLES ; RELEASE ; VIVO
英文摘要

Nanogels based on the polymers of galactosylated chitosan-graft-poly (N-isopropylacrylamide) (Gal-CS-g-PNIPAm) were used as carriers of oridonin (ORI) for tumor targeting. Three ORI-loaded nanogels with various degrees of galactose substitution were prepared, and their characteristics were evaluated. The release behavior of ORI from these nanogels was pH-dependent, and the release could be accelerated under mildly acidic conditions. The cytotoixicity of ORI-loaded nanogels was pH-sensitive. ORI-loaded nanogels exhibited a higher antitumor activity than drug-loaded nanogels without galactosylation, and the anticancer activity increased in relation to increases in the number of galactose moieties of the nanogels in HepG2 cells. In contrast, the cytotoxicity of ORI-loaded nanogels against MCF-7 cells decreased compared with that of drug-loaded nanogels without galactosylation. Results demonstrated that these nanogels could enhance the uptake of ORI into HepG2 cells via asialoglycoprotein receptor-mediated endocytosis. These galactose-decorated pH-responsive nanogels were well-suited for targeted drug delivery to liver cancer cells.

语种英语
所属项目编号81073054 ; 2009CB930300
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Basic Research Program of China
WOS记录号WOS:000297782100020
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66289
专题北京大学药学院
作者单位1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Jinan 250012, Peoples R China
3.Shandong Univ, Sch Pharmaceut Sci, Natl Glycoengn Res Ctr, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Duan, Cunxian,Gao, Jian,Zhang, Dianrui,et al. Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin[J]. BIOMACROMOLECULES,2011,12(12):4335-4343.
APA Duan, Cunxian.,Gao, Jian.,Zhang, Dianrui.,Jia, Lejiao.,Liu, Yue.,...&Zhang, Qiang.(2011).Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin.BIOMACROMOLECULES,12(12),4335-4343.
MLA Duan, Cunxian,et al."Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin".BIOMACROMOLECULES 12.12(2011):4335-4343.
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