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学科主题: 临床医学
题名:
Clinical implications of fibroblast activation protein-alpha in non-small cell lung cancer after curative resection: a new predictor for prognosis
作者: Liao, Yida1,2; Ni, Yang1; He, Ren3; Liu, Weidong4; Du, Jiajun1
关键词: Fibroblast activation protein-alpha ; Non-small cell lung cancer ; Peripheral neutrophil and lymphocyte count ratio ; Prognosis ; Inflammation
刊名: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
发表日期: 2013-09-01
DOI: 10.1007/s00432-013-1471-8
卷: 139, 期:9, 页:1523-1528
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TO-LYMPHOCYTE RATIO ; STROMAL FIBROBLASTS ; EPITHELIAL CANCERS ; SERINE-PROTEASE ; POOR-PROGNOSIS ; STELLATE CELLS ; CARCINOMA ; NEUTROPHIL ; SURVIVAL ; GELATINASE
英文摘要:

Fibroblast activation protein-alpha (FAP-alpha), which is a serine protease specially expressed on the surface of the cancer stromal cells, plays an important role in the progression and prognosis in diverse malignancies. However, the role of FAP-alpha in non-small cell lung cancer (NSCLC) is still unknown.

We enrolled 59 NSCLC patients who received complete resection. Sections of paraffin-embedded primary NSCLC specimens of all the patients were stained with antibody directed against FAP-alpha. Overall, percentage (Grade 0-3) and intensity (0-3+) of stromal FAP-alpha staining of the tumor were assessed.

FAP-alpha was detected in > 76 % of the specimens examined, and its high expression seemed to be correlated with poor tumor differentiation (P = 0.06). Furthermore, both increased FAP-alpha staining percentage and intensity were associated with worse overall survival of the patients (percentage, P = 0.0087; intensity, P = 0.05). Higher FAP-alpha staining percentage was observed in those patients with increased peripheral neutrophil and lymphocyte count ratio (P = 0.034).

FAP-alpha is highly expressed in cancer stroma and also a predictor of poor survival of NSCLC patients. Elevated FAP-alpha expression may be associated with inflammation and suppressed lymphocyte-dependent immune response, which then result in the tumor progression. Therefore, FAP-alpha plays an important role in the progression of NSCLC, and its high expression is a predictor of poor survival. Targeting FAP-alpha may be a novel strategy for NSCLC therapy.

语种: 英语
所属项目编号: 2011GGH 21819 ; 2012G0021836
项目资助者: Provincial Science and Technology Development Planning of Shandong
WOS记录号: WOS:000323250700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66301
Appears in Collections:北京大学第二临床医学院_胸外科_期刊论文

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作者单位: 1.Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250021, Peoples R China
2.Peking Univ, Dept Thorac Surg, Peoples Hosp, Beijing 100871, Peoples R China
3.Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA
4.Shandong Univ, Prov Hosp, Dept Med Imaging, Jinan 250021, Peoples R China

Recommended Citation:
Liao, Yida,Ni, Yang,He, Ren,et al. Clinical implications of fibroblast activation protein-alpha in non-small cell lung cancer after curative resection: a new predictor for prognosis[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2013,139(9):1523-1528.
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