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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population
作者: Pan, Kai-Feng1; Formichella, Luca2; Zhang, Lian1; Zhang, Yang1; Ma, Jun-Ling1; Li, Zhe-Xuan1; Liu, Cong1; Wang, Yu-Mei1; Goettner, Gereon3; Ulm, Kurt2; Classen, Meinhard2; You, Wei-Cheng1; Gerhard, Markus2,4
关键词: Helicobacter pylori ; protein ; serology ; gastric cancer ; precancerous gastric lesions
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2014-05-01
DOI: 10.1002/ijc.28560
卷: 134, 期:9, 页:2118-2125
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GAMMA-GLUTAMYL-TRANSPEPTIDASE ; MULTIPLEX SEROLOGY ; VIRULENCE FACTORS ; SERUM ANTIBODIES ; IMMUNE-RESPONSE ; HIGH-RISK ; CANCER ; INFECTION ; PREVALENCE ; PROTEINS
英文摘要:

Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylori-specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42-4.55) for IM and 2.38 (95% CI = 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27-6.59) and 2.20 (95% CI = 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p(for trend) = 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.

语种: 英语
所属项目编号: 2010DFB30310 ; 2010CB529303 ; 81171989 ; KF2016101SK0 ; CHN 11/021
项目资助者: Key International S&amp ; T Cooperation Project ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; BMWi (ZentralesInnovationsprogrammMittelstand) ; International Office BMBF ; DZIF German Centre for Infection Research, Munchen, Germany
WOS记录号: WOS:000331006600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66303
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.Mikrogen Diagnost, Neuried, Germany
2.DZIF German Ctr Infect Res, Munich, Germany
3.Peking Univ Canc Hosp & Inst, Dept Canc Epidemiol, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
4.Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-80290 Munich, Germany

Recommended Citation:
Pan, Kai-Feng,Formichella, Luca,Zhang, Lian,et al. Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population[J]. INTERNATIONAL JOURNAL OF CANCER,2014,134(9):2118-2125.
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