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A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study
Wang, Ying1; Huang, Yueqin1; Liu, Zhaorui1; Zhuo, Chuanjun1; Li, Shuran1; Prince, Martin2
关键词dementia survival time prognostic factor prognostic index
刊名INTERNATIONAL PSYCHOGERIATRICS
2010-08-01
DOI10.1017/S1041610210000669
22期:5页:761-768
收录类别SCI ; SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Geriatrics & Gerontology ; Gerontology ; Psychiatry ; Psychology
研究领域[WOS]Psychology ; Geriatrics & Gerontology ; Psychiatry
关键词[WOS]APOLIPOPROTEIN-E GENOTYPE ; ALZHEIMERS-DISEASE ; FOLLOW-UP ; HEPATOCELLULAR-CARCINOMA ; DEVELOPING-COUNTRIES ; VASCULAR DEMENTIA ; PROGNOSTIC INDEX ; MORTALITY ; DIAGNOSIS ; ONSET
英文摘要

Background: Despite the magnitude of dementia, little research on survival duration and prognosis of dementia has been reported in developing countries. This study was conducted to investigate survival times, identify related prognostic factors and construct a prognostic index (PI) for community-based dementia patients in Beijing, China.

Methods: This study is part of the 10/66 Dementia Research Group study in China. One hundred and thirty-seven dementia patients identified by 10/66 dementia criteria among 2162 participants and 137 referent subjects matched by age and sex were followed up for five years.

Results: Ninety-one (66.4%) dementia patients and 51(37.2%) referent subjects died during the 5-year follow-up (p < 0.01). The median survival time of dementia patients was 4.2 years (95% CI: 3.8-4.6). Severity of dementia (severe/mild, HR: 8.765, 95% CI: 4.436-17.163), substantial disability (HR: 5.503, 95% CI: 3.017-8.135), co-morbidity (HR: 4.149, 95% CI: 2.254-7.736) and age (HR: 1.079, 95% CI: 1.048-1.110) were independent predictors of survival for patients with dementia. Using the PI calculated for each dementia patient, all dementia patients were classified into three groups: low, medium and high risk groups. The median survival times of each group were 5.2 years, 4.4 years and 1.5 years (p < 0.01), respectively.

Conclusions: Survival times of community-based dementia patients were significantly shorter than those of referent subjects. Severity of dementia, substantial disability, co-morbidity and age were independent predictors of survival. The PI derived from the four predictors can stratify the mortality risk and predict life expectancy for community-dwelled dementia patients, although further validation is needed.

语种英语
WOS记录号WOS:000280417100010
项目编号GR08002
资助机构Wellcome Trust
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66313
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Kings Coll London, Sect Epidemiol Hlth Setv & Populat Res, London, England
推荐引用方式
GB/T 7714
Wang, Ying,Huang, Yueqin,Liu, Zhaorui,et al. A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study[J]. INTERNATIONAL PSYCHOGERIATRICS,2010,22(5):761-768.
APA Wang, Ying,Huang, Yueqin,Liu, Zhaorui,Zhuo, Chuanjun,Li, Shuran,&Prince, Martin.(2010).A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study.INTERNATIONAL PSYCHOGERIATRICS,22(5),761-768.
MLA Wang, Ying,et al."A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study".INTERNATIONAL PSYCHOGERIATRICS 22.5(2010):761-768.
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