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学科主题: 精神卫生
题名:
A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study
作者: Wang, Ying1; Huang, Yueqin1; Liu, Zhaorui1; Zhuo, Chuanjun1; Li, Shuran1; Prince, Martin2
关键词: dementia ; survival time ; prognostic factor ; prognostic index
刊名: INTERNATIONAL PSYCHOGERIATRICS
发表日期: 2010-08-01
DOI: 10.1017/S1041610210000669
卷: 22, 期:5, 页:761-768
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Geriatrics & Gerontology ; Gerontology ; Psychiatry ; Psychology
研究领域[WOS]: Psychology ; Geriatrics & Gerontology ; Psychiatry
关键词[WOS]: APOLIPOPROTEIN-E GENOTYPE ; ALZHEIMERS-DISEASE ; FOLLOW-UP ; HEPATOCELLULAR-CARCINOMA ; DEVELOPING-COUNTRIES ; VASCULAR DEMENTIA ; PROGNOSTIC INDEX ; MORTALITY ; DIAGNOSIS ; ONSET
英文摘要:

Background: Despite the magnitude of dementia, little research on survival duration and prognosis of dementia has been reported in developing countries. This study was conducted to investigate survival times, identify related prognostic factors and construct a prognostic index (PI) for community-based dementia patients in Beijing, China.

Methods: This study is part of the 10/66 Dementia Research Group study in China. One hundred and thirty-seven dementia patients identified by 10/66 dementia criteria among 2162 participants and 137 referent subjects matched by age and sex were followed up for five years.

Results: Ninety-one (66.4%) dementia patients and 51(37.2%) referent subjects died during the 5-year follow-up (p < 0.01). The median survival time of dementia patients was 4.2 years (95% CI: 3.8-4.6). Severity of dementia (severe/mild, HR: 8.765, 95% CI: 4.436-17.163), substantial disability (HR: 5.503, 95% CI: 3.017-8.135), co-morbidity (HR: 4.149, 95% CI: 2.254-7.736) and age (HR: 1.079, 95% CI: 1.048-1.110) were independent predictors of survival for patients with dementia. Using the PI calculated for each dementia patient, all dementia patients were classified into three groups: low, medium and high risk groups. The median survival times of each group were 5.2 years, 4.4 years and 1.5 years (p < 0.01), respectively.

Conclusions: Survival times of community-based dementia patients were significantly shorter than those of referent subjects. Severity of dementia, substantial disability, co-morbidity and age were independent predictors of survival. The PI derived from the four predictors can stratify the mortality risk and predict life expectancy for community-dwelled dementia patients, although further validation is needed.

语种: 英语
所属项目编号: GR08002
项目资助者: Wellcome Trust
WOS记录号: WOS:000280417100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66313
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Kings Coll London, Sect Epidemiol Hlth Setv & Populat Res, London, England

Recommended Citation:
Wang, Ying,Huang, Yueqin,Liu, Zhaorui,et al. A five-year community-based longitudinal survival study of dementia in Beijing, China: a 10/66 Dementia Research Group population-based study[J]. INTERNATIONAL PSYCHOGERIATRICS,2010,22(5):761-768.
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