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学科主题临床医学
Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside
Xu, Xinye1; Li, Zijian; Gao, Wei
关键词GDF-15 cardiovascular disease myocardial protection
刊名BIOMARKERS
2011-09-01
DOI10.3109/1354750X.2011.580006
16期:6页:466-475
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]MACROPHAGE-INHIBITORY CYTOKINE-1 ; ACUTE CORONARY SYNDROME ; DRUG-ACTIVATED GENE ; BETA SUPERFAMILY MEMBER ; PROSTATE-CANCER CELLS ; CHRONIC HEART-FAILURE ; RISK STRATIFICATION ; INDUCED APOPTOSIS ; CARCINOMA-CELLS ; MYOCARDIAL-INFARCTION
英文摘要

Context: Growth differentiation factor 15 (GDF-15) is a novel cytokine showing close association with cardiovascular diseases. The biological mechanism and clinical use of GDF-15 in cardiovascular diseases have been well demonstrated. We review recent investigations from both basic research and clinical trials into the biological role of GDF-15.

Methods: The data were obtained mainly from MedLine via PubMed and from our own investigations.

Results: Laboratory investigations revealed that GDF-15 has biphasic effects on cellular survival by several signaling pathways. GDF-15 participates in several cardiovascular pathological processes such as cardiac remodeling, ischemia/reperfusion injury and atherosclerotic plaque formation. As well, GDF-15 was found a prognostic biomarker of heart failure and acute coronary syndrome. The evidence for diagnostic or therapeutic utility is poor.

Conclusion: GDF-15 has great potential as a biomarker in cardiovascular diseases, especially for prognosis, and is seen as a myocardial protective cytokine, but the exact mechanism of GDF-15 in cardiovascular diseases remains unknown.

语种英语
WOS记录号WOS:000294117700002
项目编号2007cb512107 ; 2011CB503903 ; 81070078 ; 7102158
资助机构National Basic Research Program of China ; National Science Foundation of China ; Beijing Municipal Natural Science Foundation
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66314
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100091, Peoples R China
2.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Hosp 3, Minist Hlth, Beijing 100091, Peoples R China
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GB/T 7714
Xu, Xinye,Li, Zijian,Gao, Wei. Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside[J]. BIOMARKERS,2011,16(6):466-475.
APA Xu, Xinye,Li, Zijian,&Gao, Wei.(2011).Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside.BIOMARKERS,16(6),466-475.
MLA Xu, Xinye,et al."Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside".BIOMARKERS 16.6(2011):466-475.
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