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学科主题: 临床医学
题名:
Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside
作者: Xu, Xinye1; Li, Zijian; Gao, Wei
关键词: GDF-15 ; cardiovascular disease ; myocardial protection
刊名: BIOMARKERS
发表日期: 2011-09-01
DOI: 10.3109/1354750X.2011.580006
卷: 16, 期:6, 页:466-475
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: MACROPHAGE-INHIBITORY CYTOKINE-1 ; ACUTE CORONARY SYNDROME ; DRUG-ACTIVATED GENE ; BETA SUPERFAMILY MEMBER ; PROSTATE-CANCER CELLS ; CHRONIC HEART-FAILURE ; RISK STRATIFICATION ; INDUCED APOPTOSIS ; CARCINOMA-CELLS ; MYOCARDIAL-INFARCTION
英文摘要:

Context: Growth differentiation factor 15 (GDF-15) is a novel cytokine showing close association with cardiovascular diseases. The biological mechanism and clinical use of GDF-15 in cardiovascular diseases have been well demonstrated. We review recent investigations from both basic research and clinical trials into the biological role of GDF-15.

Methods: The data were obtained mainly from MedLine via PubMed and from our own investigations.

Results: Laboratory investigations revealed that GDF-15 has biphasic effects on cellular survival by several signaling pathways. GDF-15 participates in several cardiovascular pathological processes such as cardiac remodeling, ischemia/reperfusion injury and atherosclerotic plaque formation. As well, GDF-15 was found a prognostic biomarker of heart failure and acute coronary syndrome. The evidence for diagnostic or therapeutic utility is poor.

Conclusion: GDF-15 has great potential as a biomarker in cardiovascular diseases, especially for prognosis, and is seen as a myocardial protective cytokine, but the exact mechanism of GDF-15 in cardiovascular diseases remains unknown.

语种: 英语
所属项目编号: 2007cb512107 ; 2011CB503903 ; 81070078 ; 7102158
项目资助者: National Basic Research Program of China ; National Science Foundation of China ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000294117700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66314
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100091, Peoples R China
2.Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Hosp 3, Minist Hlth, Beijing 100091, Peoples R China

Recommended Citation:
Xu, Xinye,Li, Zijian,Gao, Wei. Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside[J]. BIOMARKERS,2011,16(6):466-475.
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