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学科主题: 临床医学
题名:
Effect of curettage and copper wire on rabbit endometrium: a novel rabbit model of endometrial mechanical injury
作者: Li Li1; Shi Jing2; Zhang Qiu-fang1; Yan Jie1; Yan Li-ying1; Shen Fei2; Qiao Jie1; Feng Huai-liang1,3
关键词: endometrium ; injury ; repair ; animal model
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-06-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.11.019
卷: 124, 期:11, 页:1708-1713
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: VAGINAL SILDENAFIL ; WOUND REPAIR ; IN-VITRO ; REGENERATION ; THERAPY ; CITRATE ; PHASE ; WOMEN ; IVF
英文摘要:

Background It remains almost a helpless situation for the recurrent implantation failure and pregnancy loss caused by endometrial injury at present. The purpose of this study was to develop a rabbit model of endometrial mechanical injury that could provide a research platform for this difficult clinical predicament.

Methods Three experiments were conducted. Experiment 1: Curettages in both uterus horns and copper wire inserting after curettage (double-injury) in one horn. The histological changes were monitored at 0, 24, 48, 72 hours, as well as in 1 and 2 weeks after operation. Experiment 2: Direct copper wire inserting in one horn and double-injury in other horn. The wires in both horns were removed after 2 weeks. The histological changes were recorded at 0, 1 and 2 weeks after wire removal. Experiment 3: Double-injury procedure in one horn was performed and wire was removed after 2 weeks; another horn was remained normal to serve as control. Histological changes were recorded, tissue areas were measured, and proliferation indices (PIs, %) were calculated at 1, 2, 4 and 8 weeks after wire removal, respectively.

Results The experiments revealed that the injured endometrium by simple curettage or copper wire could be fully repaired. While the endometrial regeneration was severely impaired by double-injury, both areas of endometrium and uterine cavity decreased (P <0.05); both Pis of glandular epithelial and stromal cells increased and reached maximum at 4 weeks (P <0.05), but returned by 8 weeks.

Conclusion This study demonstrated that a rabbit model of endometrial injury could be effectively established through a double-injury procedure of curettage and copper wire with comparable clinical index. Chin Med J 2011;124(11):1708-1713

语种: 英语
所属项目编号: 2007-1002 ; BMU20090514-603 ; JSW08-7-08
项目资助者: Capital Medical Development Scientific Research Fund ; Fundamental Research Funds for the Central Universities ; National Population and Family Planning Commission of China
WOS记录号: WOS:000292350000020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66315
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Lab Anim Sci, Beijing 100191, Peoples R China
3.Hofstra Univ, Sch Med, N Shore Univ Hosp LIJ, Ctr Human Reprod,Dept Obstet & Gynecol, Manhasset, NY 10030 USA

Recommended Citation:
Li Li,Shi Jing,Zhang Qiu-fang,et al. Effect of curettage and copper wire on rabbit endometrium: a novel rabbit model of endometrial mechanical injury[J]. CHINESE MEDICAL JOURNAL,2011,124(11):1708-1713.
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