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Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
Zhou, Yue1; Yu, Peilin1; Jin, Hongwei1; Yang, Zhenjun1; Yue, Jianbo2; Zhang, Liangren1; Zhang, Lihe1
关键词cADPR analogue nucleotide synthesis calcium mobilization
刊名MOLECULES
2012-04-01
DOI10.3390/molecules17044343
17期:4页:4343-4356
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CYCLIC ADP-RIBOSE ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; CA2+-MOBILIZING ACTIVITY ; 5-DIPHOSPHATE RIBOSE ; CARBOCYCLIC-RIBOSE ; RELEASE ACTIVITY ; T-LYMPHOCYTES ; CHEMISTRY ; DERIVATIVES ; MIMICS
英文摘要

Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Huisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2′-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3′-OH of the southern riboses does not obviously alter the agonistic activity.

语种英语
WOS记录号WOS:000303309900051
项目编号90713005 ; 20910094 ; 200800010078
资助机构National Natural Sciences Foundation of China ; Ministry of Education of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66319
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
北京大学第三临床医学院_手术室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Yue,Yu, Peilin,Jin, Hongwei,et al. Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications[J]. MOLECULES,2012,17(4):4343-4356.
APA Zhou, Yue.,Yu, Peilin.,Jin, Hongwei.,Yang, Zhenjun.,Yue, Jianbo.,...&Zhang, Lihe.(2012).Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications.MOLECULES,17(4),4343-4356.
MLA Zhou, Yue,et al."Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications".MOLECULES 17.4(2012):4343-4356.
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