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学科主题: 药学
题名:
Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
作者: Zhou, Yue1; Yu, Peilin1; Jin, Hongwei1; Yang, Zhenjun1; Yue, Jianbo2; Zhang, Liangren1; Zhang, Lihe1
关键词: cADPR analogue ; nucleotide ; synthesis ; calcium mobilization
刊名: MOLECULES
发表日期: 2012-04-01
DOI: 10.3390/molecules17044343
卷: 17, 期:4, 页:4343-4356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CYCLIC ADP-RIBOSE ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; CA2+-MOBILIZING ACTIVITY ; 5-DIPHOSPHATE RIBOSE ; CARBOCYCLIC-RIBOSE ; RELEASE ACTIVITY ; T-LYMPHOCYTES ; CHEMISTRY ; DERIVATIVES ; MIMICS
英文摘要:

Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Huisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2′-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3′-OH of the southern riboses does not obviously alter the agonistic activity.

语种: 英语
所属项目编号: 90713005 ; 20910094 ; 200800010078
项目资助者: National Natural Sciences Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000303309900051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66319
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhou, Yue,Yu, Peilin,Jin, Hongwei,et al. Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications[J]. MOLECULES,2012,17(4):4343-4356.
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