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Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors
Ji, Shuai1; Qiao, Xue1; Li, Zi-wei1; Wang, Yong-rui1; Yu, Si-wang1; Liang, Wen-fei1; Lin, Xiong-hao1; Ye, Min1,2
刊名RSC ADVANCES
2015
DOI10.1039/c5ra06452j
5期:56页:45258-45265
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]ABSOLUTE-CONFIGURATION ; DERIVATIVES ; FLAVONOIDS ; COUMARINS ; CONSTITUENTS ; LICORICE ; DISCOVERY ; OBESITY ; ACID
英文摘要

Glycyfuranocoumarin A-C (1-3), three 3-arylcoumarins, and glycyfuranocoumarone A (4), one 2-arylcoumarone, were isolated in the racemic form from the roots of Glycyrrhiza uralensis. Their structures were elucidated by NMR, 2D NMR and HRESIMS data analyses. All the structures contain a 2,3-dihydro-2,3,3-trimethylbenzofuran ring. Chiral HPLC was used to obtain the optically pure enantiomers, (2 ′′ R)-1 and (2 ′′ S)-1. Their absolute configurations were determined by X-ray crystallography. This is the first unambiguous determination of the absolute configuration of 2,3-dihydro-2,3,3-trimethylbenzofurans. (2 ′′ R)-1 and (2 ′′ S)-1, as well as 2-4, exhibited significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Among them, 4 showed an IC50 of 2.2 mu M.

语种英语
WOS记录号WOS:000354965300062
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66323
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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GB/T 7714
Ji, Shuai,Qiao, Xue,Li, Zi-wei,et al. Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors[J]. RSC ADVANCES,2015,5(56):45258-45265.
APA Ji, Shuai.,Qiao, Xue.,Li, Zi-wei.,Wang, Yong-rui.,Yu, Si-wang.,...&Ye, Min.(2015).Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors.RSC ADVANCES,5(56),45258-45265.
MLA Ji, Shuai,et al."Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors".RSC ADVANCES 5.56(2015):45258-45265.
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