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学科主题: 药学
题名:
Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors
作者: Ji, Shuai1; Qiao, Xue1; Li, Zi-wei1; Wang, Yong-rui1; Yu, Si-wang1; Liang, Wen-fei1; Lin, Xiong-hao1; Ye, Min1,2
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra06452j
卷: 5, 期:56, 页:45258-45265
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: ABSOLUTE-CONFIGURATION ; DERIVATIVES ; FLAVONOIDS ; COUMARINS ; CONSTITUENTS ; LICORICE ; DISCOVERY ; OBESITY ; ACID
英文摘要:

Glycyfuranocoumarin A-C (1-3), three 3-arylcoumarins, and glycyfuranocoumarone A (4), one 2-arylcoumarone, were isolated in the racemic form from the roots of Glycyrrhiza uralensis. Their structures were elucidated by NMR, 2D NMR and HRESIMS data analyses. All the structures contain a 2,3-dihydro-2,3,3-trimethylbenzofuran ring. Chiral HPLC was used to obtain the optically pure enantiomers, (2 ′′ R)-1 and (2 ′′ S)-1. Their absolute configurations were determined by X-ray crystallography. This is the first unambiguous determination of the absolute configuration of 2,3-dihydro-2,3,3-trimethylbenzofurans. (2 ′′ R)-1 and (2 ′′ S)-1, as well as 2-4, exhibited significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Among them, 4 showed an IC50 of 2.2 mu M.

语种: 英语
所属项目编号: 81173644 ; 81222054 ; NCET-11-0019
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from Chinese Ministry of Education ; State Key Laboratory of Drug Research
WOS记录号: WOS:000354965300062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66323
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

Recommended Citation:
Ji, Shuai,Qiao, Xue,Li, Zi-wei,et al. Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors[J]. RSC ADVANCES,2015,5(56):45258-45265.
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