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学科主题: 临床医学
题名:
C-KIT mutations were closely associated with the response to Imatinib in Chinese advanced gastrointestinal stromal tumor patients
作者: Gao, Jing; Dang, Yunzhi; Sun, Naiping; Li, Jian; Shen, Lin
关键词: Chinese GIST ; C-KIT/PDGFR alpha ; Mutation ; Imatinib ; Response
刊名: MEDICAL ONCOLOGY
发表日期: 2012-12-01
DOI: 10.1007/s12032-012-0308-7
卷: 29, 期:5, 页:3039-3045
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SIGNAL-TRANSDUCTION ; PDGFRA MUTATIONS ; KINASE MUTATIONS ; TYROSINE KINASE ; KOREAN PATIENTS ; MESYLATE ; EFFICACY ; EXPRESSION ; GIST ; SAFETY
英文摘要:

To investigate the correlation between C-KIT/PDGFR alpha mutations and Imatinib response or survival in Chinese advanced gastrointestinal stromal tumor (GIST) patients. Clinical data and paraffin-embedded tumor specimens were collected from 158 advanced GIST patients receiving first-line Imatinib. Mutation analyses of C-KIT gene (Exons 9, 11, 13, and 17) and PDGFR alpha gene (exons 12 and 18) were performed by PCR amplification and Sanger sequencing. A total of 135 patients harboring C-KIT mutations (exon 11 mutation: 108; exon 9 mutation: 23; exon 13 mutation: 2; exon 17 mutation: 2) and one patients carrying PDGFR alpha mutation (exon 18) were found in this study. Twenty-two patients (13.9 %) with neither C-KIT nor PDGFR alpha mutations were named as wild type. The response rate (64.7 vs. 36.4 %, P = 0.000) and median progression-free survival (28 vs. 8 months, P = 0.000) of mutant patients (n = 136) were significantly higher than those of wild-type patients (n = 22). Moreover, the response rate and median progression-free survival in patients with exon 11 mutations (n = 108), exon 9 mutations (n = 23), and wild-type patients (n = 22) were 68.5, 47.8, and 36.4 % (P = 0.001), and 31 months, 13 months, and 8 months (P = 0.000), respectively. No significant differences of response rate or median progression-free survival were seen in patients with exon 11 deletion mutations, point mutations, and mixed-type mutations. C-KIT mutations were closely associated with Imatinib response and progression-free survival of Chinese advanced GIST patients. Other predictive markers for Imatinib would be further investigated.

语种: 英语
WOS记录号: WOS:000311513800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66324
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: Peking Univ Canc Hosp & Inst, Dept GI Oncol, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Gao, Jing,Dang, Yunzhi,Sun, Naiping,et al. C-KIT mutations were closely associated with the response to Imatinib in Chinese advanced gastrointestinal stromal tumor patients[J]. MEDICAL ONCOLOGY,2012,29(5):3039-3045.
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