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学科主题临床医学
Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting
Yang, Jun; Cai, Hong; Lv, Jia; Zhang, Ke; Leng, Huijie; Wang, Zhiguo; Liu, Zhongjun
刊名PLOS ONE
2014-04-30
DOI10.1371/journal.pone.0096179
9期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Project of Scientific and Technical Plan of Beijing ; Project of Scientific and Technical Plan of Beijing
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MESENCHYMAL STEM-CELLS ; POROUS TITANIUM ; DENTAL IMPLANTS ; DIFFERENTIATION ; BEHAVIOR ; OSSEOINTEGRATION ; OSTEOINDUCTION ; STRENGTH ; REMOVAL ; GROWTH
英文摘要

Background: Various fabrication methods are used to improve the stability and osseointegration of screws within the host bone. The aim of this study was to investigate whether roughened surface titanium screws fabricated by electron beam melting can provide better stability and osseointegration as compared with smooth titanium screws in sheep cervical vertebrae.

Methods: Roughened surface titanium screws, fabricated by electron beam melting, and conventional smooth surface titanium screws were implanted into sheep for 6 or 12 weeks (groups A and B, respectively). Bone ingrowth and implant stability were assessed with three-dimensional imaging and reconstruction, as well as histological and biomechanical tests.

Results: No screws in either group showed signs of loosening. Fibrous tissue formation could be seen around the screws at 6 weeks, which was replaced with bone at 12 weeks. Bone volume/total volume, bone surface area/bone volume, and the trabecular number were significantly higher for a define region of interest surrounding the roughened screws than that surrounding the smooth screws at 12 weeks. Indeed, for roughened screws, trabecular number was significantly higher at 12 weeks than at 6 weeks. On mechanical testing, the maximum pullout strength was significantly higher at 12 weeks than at 6 weeks, as expected; however, no significant differences were found between smooth and roughened screws at either time point. The maximum torque to extract the roughened screws was higher than that required for the smooth screws.

Conclusions: Electron beam melting is a simple and effective method for producing a roughened surface on titanium screws. After 12 weeks, roughened titanium screws demonstrated a high degree of osseointegration and increased torsional resistance to extraction over smooth titanium screws.

语种英语
所属项目编号Z121100005312005
资助者Project of Scientific and Technical Plan of Beijing ; Project of Scientific and Technical Plan of Beijing
WOS记录号WOS:000338917300031
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66329
专题北京大学第三临床医学院_骨科
作者单位Peking Univ, Hosp 3, Dept Orthoped, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Jun,Cai, Hong,Lv, Jia,et al. Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting[J]. PLOS ONE,2014,9(4).
APA Yang, Jun.,Cai, Hong.,Lv, Jia.,Zhang, Ke.,Leng, Huijie.,...&Liu, Zhongjun.(2014).Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting.PLOS ONE,9(4).
MLA Yang, Jun,et al."Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting".PLOS ONE 9.4(2014).
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