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学科主题: 临床医学
题名:
Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting
作者: Yang, Jun; Cai, Hong; Lv, Jia; Zhang, Ke; Leng, Huijie; Wang, Zhiguo; Liu, Zhongjun
刊名: PLOS ONE
发表日期: 2014-04-30
DOI: 10.1371/journal.pone.0096179
卷: 9, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MESENCHYMAL STEM-CELLS ; POROUS TITANIUM ; DENTAL IMPLANTS ; DIFFERENTIATION ; BEHAVIOR ; OSSEOINTEGRATION ; OSTEOINDUCTION ; STRENGTH ; REMOVAL ; GROWTH
英文摘要:

Background: Various fabrication methods are used to improve the stability and osseointegration of screws within the host bone. The aim of this study was to investigate whether roughened surface titanium screws fabricated by electron beam melting can provide better stability and osseointegration as compared with smooth titanium screws in sheep cervical vertebrae.

Methods: Roughened surface titanium screws, fabricated by electron beam melting, and conventional smooth surface titanium screws were implanted into sheep for 6 or 12 weeks (groups A and B, respectively). Bone ingrowth and implant stability were assessed with three-dimensional imaging and reconstruction, as well as histological and biomechanical tests.

Results: No screws in either group showed signs of loosening. Fibrous tissue formation could be seen around the screws at 6 weeks, which was replaced with bone at 12 weeks. Bone volume/total volume, bone surface area/bone volume, and the trabecular number were significantly higher for a define region of interest surrounding the roughened screws than that surrounding the smooth screws at 12 weeks. Indeed, for roughened screws, trabecular number was significantly higher at 12 weeks than at 6 weeks. On mechanical testing, the maximum pullout strength was significantly higher at 12 weeks than at 6 weeks, as expected; however, no significant differences were found between smooth and roughened screws at either time point. The maximum torque to extract the roughened screws was higher than that required for the smooth screws.

Conclusions: Electron beam melting is a simple and effective method for producing a roughened surface on titanium screws. After 12 weeks, roughened titanium screws demonstrated a high degree of osseointegration and increased torsional resistance to extraction over smooth titanium screws.

语种: 英语
所属项目编号: Z121100005312005
项目资助者: Project of Scientific and Technical Plan of Beijing
WOS记录号: WOS:000338917300031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66329
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Jun,Cai, Hong,Lv, Jia,et al. Biomechanical and Histological Evaluation of Roughened Surface Titanium Screws Fabricated by Electron Beam Melting[J]. PLOS ONE,2014,9(4).
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