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学科主题: 临床医学
题名:
High-dose Ambroxol Reduces Pulmonary Complications in Patients with Acute Cervical Spinal Cord Injury After Surgery
作者: Li, Qiang; Yao, Gaiqi; Zhu, Xi
关键词: Ambroxol ; Cervical spinal cord injury ; Pulmonary complications
刊名: NEUROCRITICAL CARE
发表日期: 2012-04-01
DOI: 10.1007/s12028-011-9642-4
卷: 16, 期:2, 页:267-272
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Clinical Neurology
研究领域[WOS]: General & Internal Medicine ; Neurosciences & Neurology
关键词[WOS]: ACUTE LUNG INJURY ; LOWER TIDAL VOLUMES ; MECHANICAL VENTILATION ; BRONCHOPULMONARY COMPLICATIONS ; INFLAMMATORY RESPONSES ; CELLS ; MODEL ; AMOXICILLIN ; INTUBATION ; STRATEGIES
英文摘要:

Background Ambroxol has a very high affinity for lung tissues; its concentration is approximately 20 times higher in the lung than in the serum. We aimed to evaluate the effectiveness of high-dose ambroxol (990 mg/day) in the improvement of oxygenation and prevention of postoperative respiratory complications in the patients with acute cervical spinal cord injury (CSCI).

Methods A total of 61 acute CSCI patients admitted to the Intensive Care Unit (ICU) of our hospital between January 2009 and June 2011 were included in the study. They were graded as ASIA A and ASIA B according to the classification of the American Spinal Injury Association (ASIA) and were randomly divided into two groups: one group received intravenous ambroxol at 990 mg/day for 5 consecutive days after operation; the other group treated without ambroxol served as control. The results of arterial blood gas analysis on postoperative day 3 and 5 and occurrence of pulmonary complications within 5 days after operation were evaluated.

Results The group treated with high-dose ambroxol showed a lower rate of postoperative pneumonia and hypoxemia within 5 days after operation. On the 3rd and 5th days, the oxygenation index in the high-dose ambroxol group (291.02 +/- 34.96 and 301.28 +/- 37.69) was significantly higher than in the control group (230.08 +/- 26.25 and 253.82 +/- 26.26), with significant differences between the two groups (P = 0.045 and 0.041).

Conclusion Administration of high-dose ambroxol should be considered as an alternative and effective approach to reduce the postoperative respiratory complications and improve the oxygenation status in acute CSCI patients.

语种: 英语
WOS记录号: WOS:000304618500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66339
Appears in Collections:北京大学第三临床医学院_危重医学科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Intens Care Unit, Beijing 100191, Peoples R China

Recommended Citation:
Li, Qiang,Yao, Gaiqi,Zhu, Xi. High-dose Ambroxol Reduces Pulmonary Complications in Patients with Acute Cervical Spinal Cord Injury After Surgery[J]. NEUROCRITICAL CARE,2012,16(2):267-272.
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