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学科主题基础医学
NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
Xing, Junyue1; Yi, Jie3; Cai, Xiaoyu1; Tang, Hao1; Liu, Zhenyun1; Zhang, Xiaotian1; Martindale, Jennifer L.2; Yang, Xiaoling2; Jiang, Bin1; Gorospe, Myriam2; Wang, Wengong1
刊名MOLECULAR AND CELLULAR BIOLOGY
2015-12-01
DOI10.1128/MCB.00742-15
35期:23页:4043-4052
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]Rna Methyltransferase Nsun2 ; Messenger-rna ; Binding Protein ; Cdk1 ; Activation ; Mitosis ; Phosphorylation ; Methylation ; Proliferation ; Transitions
英文摘要

The tRNA methytransfera se NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cycle-dependent manner. Knockdown of NSun2 decreased the CDK1 protein level, while overexpression of NSun2 elevated it without altering CDK1 mRNA levels. Further studies revealed that NSun2 methylated CDK1 mRNA in vitro and in cells and that methylation by NSun2 enhanced CDK1 translation. Importantly, NSun2-mediated regulation of CDK1 expression had an impact on the cell division cycle. These results provide new insight into the regulation of CDK1 during the cell division cycle.

语种英语
WOS记录号WOS:000365714900009
通讯作者邮箱wwg@bjmu.edu.cn
项目编号81230008 ; 81420108016 ; 91339114 ; B07001
资助机构National Science Foundation of China ; Ministry of Education of People′s Republic of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66349
专题北京大学基础医学院
北京大学药学院_药事管理与临床药学系
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol,Beijing Key Lab Prot Post, Beijing 100871, Peoples R China
2.NIA, Genet Lab, NIH, Baltimore, MD 21224 USA
3.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China
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GB/T 7714
Xing, Junyue,Yi, Jie,Cai, Xiaoyu,et al. NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation[J]. MOLECULAR AND CELLULAR BIOLOGY,2015,35(23):4043-4052.
APA Xing, Junyue.,Yi, Jie.,Cai, Xiaoyu.,Tang, Hao.,Liu, Zhenyun.,...&Wang, Wengong.(2015).NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation.MOLECULAR AND CELLULAR BIOLOGY,35(23),4043-4052.
MLA Xing, Junyue,et al."NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation".MOLECULAR AND CELLULAR BIOLOGY 35.23(2015):4043-4052.
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