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学科主题: 基础医学
题名:
NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
作者: Xing, Junyue1; Yi, Jie3; Cai, Xiaoyu1; Tang, Hao1; Liu, Zhenyun1; Zhang, Xiaotian1; Martindale, Jennifer L.2; Yang, Xiaoling2; Jiang, Bin1; Gorospe, Myriam2; Wang, Wengong1
刊名: MOLECULAR AND CELLULAR BIOLOGY
发表日期: 2015-12-01
DOI: 10.1128/MCB.00742-15
卷: 35, 期:23, 页:4043-4052
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: RNA METHYLTRANSFERASE NSUN2 ; MESSENGER-RNA ; BINDING PROTEIN ; CDK1 ; ACTIVATION ; MITOSIS ; PHOSPHORYLATION ; METHYLATION ; PROLIFERATION ; TRANSITIONS
英文摘要:

The tRNA methytransfera se NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cycle-dependent manner. Knockdown of NSun2 decreased the CDK1 protein level, while overexpression of NSun2 elevated it without altering CDK1 mRNA levels. Further studies revealed that NSun2 methylated CDK1 mRNA in vitro and in cells and that methylation by NSun2 enhanced CDK1 translation. Importantly, NSun2-mediated regulation of CDK1 expression had an impact on the cell division cycle. These results provide new insight into the regulation of CDK1 during the cell division cycle.

语种: 英语
所属项目编号: 81230008 ; 81420108016 ; 91339114 ; B07001
项目资助者: National Science Foundation of China ; Ministry of Education of People&prime ; s Republic of China
WOS记录号: WOS:000365714900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66349
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol,Beijing Key Lab Prot Post, Beijing 100871, Peoples R China
2.NIA, Genet Lab, NIH, Baltimore, MD 21224 USA
3.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China

Recommended Citation:
Xing, Junyue,Yi, Jie,Cai, Xiaoyu,et al. NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation[J]. MOLECULAR AND CELLULAR BIOLOGY,2015,35(23):4043-4052.
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