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学科主题: 临床医学
题名:
Value of fructosamine measurement in pregnant women with abnormal glucose tolerance
作者: Li Kui; Yang Hui-xia
关键词: fructosamine ; abnormal glucose tolerance ; pregnancy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2006-11-20
卷: 119, 期:22, 页:1861-1865
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GESTATIONAL DIABETES-MELLITUS ; SERUM FRUCTOSAMINE ; GLYCATED HEMOGLOBIN ; PLASMA FRUCTOSAMINE ; PROTEINS ; ALBUMIN ; RISK
英文摘要:

Background The concentration of serum fructosamine is correlated with plasma glucose level. The aim of this study was to determine whether the level of serum fructosamine can be diagnostic for abnormal glucose tolerance in pregnant women.

Methods Serum samples were collected from 161 pregnant women between November 2004 and April 2005. The women were divided into three groups according to the gestational age (16-20 weeks group, 56 patients; 28 -34 weeks group, 72; and 37-41 weeks group, 33). Each group was subdivided into normal and abnormal glucose tolerance subgroups. The levels of serum fructosamine were measured. Differences among the groups were assessed by ANOVA and Student-Newman-Keuls test. Correlations between the level of fructosamine and other variables including the results of glucose challenge test (GCT), oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) test, and infant′s birth weight were analyzed by Pearson correlation.

Results The level of serum fructosamine decreased with gestational age [(223.25 +/- 48.90) mu mol/L, (98.44 +/- 29.57) mu mol/L, and (53.99 +/- 29.94) mu mol/L, respectively. P < 0.05]. It was higher in women with abnormal glucose tolerance than that in women with normal glucose tolerance, however, the difference reached statistical significance only in the 28-34 weeks group (P < 0.05). In this group, the level of serum fructosamine correlated positively with the GCT result (1--0.28, P < 0.05). No correlation was found between fructosamine level and OGTT result, 14bAlc level, or neonatal weight.

Conclusions Fructosamine can be used to monitor the glucose level of pregnant women with abnormal glucose tolerance, and to identify the patients at high risk of abnormal glucose tolerance, but can not be used to predict gestational diabetes mellitus (GDM) in early stage of pregnancy.

语种: 英语
WOS记录号: WOS:000242328700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66355
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, First Hosp, Dept Obstet & Gynecol, Beijing 100034, Peoples R China

Recommended Citation:
Li Kui,Yang Hui-xia. Value of fructosamine measurement in pregnant women with abnormal glucose tolerance[J]. CHINESE MEDICAL JOURNAL,2006,119(22):1861-1865.
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