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学科主题: 临床医学
题名:
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
作者: Zhang, Xiuying1; Shen, Dongqian2; Fang, Zhiwei2; Jie, Zhuye2; Qiu, Xinmin2; Zhang, Chunfang3; Chen, Yingli1; Ji, Linong1
刊名: PLOS ONE
发表日期: 2013-08-27
DOI: 10.1371/journal.pone.0071108
卷: 8, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: TYPE-2 DIABETES-MELLITUS ; DIET-INDUCED OBESITY ; AKKERMANSIA-MUCINIPHILA ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; RISK-FACTORS ; BODY-WEIGHT ; LIFE-STYLE ; SP NOV. ; MICE
英文摘要:

To explore the relationship of gut microbiota with the development of type 2 diabetes (T2DM), we analyzed 121 subjects who were divided into 3 groups based on their glucose intolerance status: normal glucose tolerance (NGT; n = 44), prediabetes (Pre-DM; n = 64), or newly diagnosed T2DM (n = 13). Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. T2DM-related dysbiosis was observed, including the separation of microbial communities and a change of alpha diversity between the different glucose intolerance statuses. To assess the correlation between metabolic parameters and microbiota diversity, clinical characteristics were also measured and a significant association between metabolic parameters (FPG, CRP) and gut microbiota was found. In addition, a total of 28 operational taxonomic units (OTUs) were found to be related to T2DM status by the Kruskal-Wallis H test, most of which were enriched in the T2DM group. Butyrate-producing bacteria (e. g. Akkermansia muciniphila ATCCBAA-835, and Faecalibacterium prausnitzii L2-6) had a higher abundance in the NGT group than in the pre-DM group. At genus level, the abundance of Bacteroides in the T2DM group was only half that of the NGT and Pre-DM groups. Previously reported T2DM-related markers were also compared with the data in this study, and some inconsistencies were noted. We found that Verrucomicrobiae may be a potential marker of T2DM as it had a significantly lower abundance in both the pre-DM and T2DM groups. In conclusion, this research provides further evidence of the structural modulation of gut microbiota in the pathogenesis of diabetes.

语种: 英语
所属项目编号: 2006AA02A409
项目资助者: National High Technology Research and Development Program
WOS记录号: WOS:000323815200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66356
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.BGI Shenzhen, Shenzhen, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100871, Peoples R China
3.Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiuying,Shen, Dongqian,Fang, Zhiwei,et al. Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance[J]. PLOS ONE,2013,8(8).
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