IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
Zhang, Xiuying1; Shen, Dongqian2; Fang, Zhiwei2; Jie, Zhuye2; Qiu, Xinmin2; Zhang, Chunfang3; Chen, Yingli1; Ji, Linong1
刊名PLOS ONE
2013-08-27
DOI10.1371/journal.pone.0071108
8期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TYPE-2 DIABETES-MELLITUS ; DIET-INDUCED OBESITY ; AKKERMANSIA-MUCINIPHILA ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; RISK-FACTORS ; BODY-WEIGHT ; LIFE-STYLE ; SP NOV. ; MICE
英文摘要

To explore the relationship of gut microbiota with the development of type 2 diabetes (T2DM), we analyzed 121 subjects who were divided into 3 groups based on their glucose intolerance status: normal glucose tolerance (NGT; n = 44), prediabetes (Pre-DM; n = 64), or newly diagnosed T2DM (n = 13). Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. T2DM-related dysbiosis was observed, including the separation of microbial communities and a change of alpha diversity between the different glucose intolerance statuses. To assess the correlation between metabolic parameters and microbiota diversity, clinical characteristics were also measured and a significant association between metabolic parameters (FPG, CRP) and gut microbiota was found. In addition, a total of 28 operational taxonomic units (OTUs) were found to be related to T2DM status by the Kruskal-Wallis H test, most of which were enriched in the T2DM group. Butyrate-producing bacteria (e. g. Akkermansia muciniphila ATCCBAA-835, and Faecalibacterium prausnitzii L2-6) had a higher abundance in the NGT group than in the pre-DM group. At genus level, the abundance of Bacteroides in the T2DM group was only half that of the NGT and Pre-DM groups. Previously reported T2DM-related markers were also compared with the data in this study, and some inconsistencies were noted. We found that Verrucomicrobiae may be a potential marker of T2DM as it had a significantly lower abundance in both the pre-DM and T2DM groups. In conclusion, this research provides further evidence of the structural modulation of gut microbiota in the pathogenesis of diabetes.

语种英语
WOS记录号WOS:000323815200012
项目编号2006AA02A409
资助机构National High Technology Research and Development Program
引用统计
被引频次:130[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66356
专题北京大学第二临床医学院
北京大学临床肿瘤学院_骨与软组织肿瘤科
作者单位1.BGI Shenzhen, Shenzhen, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100871, Peoples R China
3.Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiuying,Shen, Dongqian,Fang, Zhiwei,et al. Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance[J]. PLOS ONE,2013,8(8).
APA Zhang, Xiuying.,Shen, Dongqian.,Fang, Zhiwei.,Jie, Zhuye.,Qiu, Xinmin.,...&Ji, Linong.(2013).Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance.PLOS ONE,8(8).
MLA Zhang, Xiuying,et al."Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance".PLOS ONE 8.8(2013).
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