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学科主题基础医学
Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9
Zhan, Jun1,2,3; Song, Jiagui1,2,3; Wang, Peng1,2,3; Chi, Xiaochun1,2,3; Wang, Yunling1,2,3; Guo, Yongqing4; Fang, Weigang1,2,5; Zhang, Hongquan1,2,3
关键词Kindlin-2 TGF-beta 1 HOXB9 Pancreatic cancer E-cadherin
刊名CANCER LETTERS
2015-05-28
DOI10.1016/j.canlet.2015.02.039
361期:1页:75-85
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GASTRIC-CANCER CELLS ; BREAST-CANCER ; MESENCHYMAL TRANSDIFFERENTIATION ; INTEGRIN ACTIVATION ; HOMEOBOX GENE ; IN-VITRO ; EXPRESSION ; METASTASIS ; ADHESION ; TUMOR
英文摘要

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths with no effective therapeutics. Invasion and metastasis are the major characteristics of PDAC. However, mechanisms underlying PDAC invasion and metastasis are elusive. In this report, we found that Kindlin-2 is a target protein of transforming growth factor beta (TGF-beta) signaling and is upregulated by TGF-beta 1 in PDAC cells. TGF-beta 1-upregulated Kindlin-2 promotes PDAC cell growth, migration and invasion, whereas Kindlin-2 upregulates transforming growth factor receptor I (T beta RI), a key component of TGF-beta signaling. Thereby Kindlin-2 and TGF-beta signaling constitute a positive feedback loop. Mechanistically, Kindlin-2 promotes PDAC progression by downregulation of HOXB9 and E-cadherin. For clinical relevance, enhanced expression of Kindlin-2 predicts a poor overall survival for PDAC patients. Gene expression levels of Kindlin-2, TGF-beta, VIZI and HOXB9 are all correlated with the overall survival of PDAC patients in an Oncomine dataset. Taken together, our findings demonstrated that TGF-beta 1-induced Kindlin-2 expression promotes PDAC progression by downregulation of HOXB9 and E-cadherin. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000352675500010
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66362
专题北京大学基础医学院_病理学系
北京大学医学部管理机构_主任办公室党委办公室
北京大学基础医学院
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
4.Sinojapan Friendship Hosp, Dept Thorac Surg, Beijing 100123, Peoples R China
5.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Zhan, Jun,Song, Jiagui,Wang, Peng,et al. Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9[J]. CANCER LETTERS,2015,361(1):75-85.
APA Zhan, Jun.,Song, Jiagui.,Wang, Peng.,Chi, Xiaochun.,Wang, Yunling.,...&Zhang, Hongquan.(2015).Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9.CANCER LETTERS,361(1),75-85.
MLA Zhan, Jun,et al."Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9".CANCER LETTERS 361.1(2015):75-85.
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