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Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice
Sun, Yan-Ping; Liu, Qing; Luo, Juan; Guo, Ping; Chen, Feng2; Lawrence, Andrew J.3; Liang, Jian-Hui1
关键词Ethanol Pentobarbital Arecoline Muscarinic Receptor Loss of the Righting Reflex
刊名ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
2010
DOI10.1111/j.1530-0277.2009.01076.x
34期:1页:150-157
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse
研究领域[WOS]Substance Abuse
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; FREELY MOVING RATS ; ACETYLCHOLINE-RELEASE ; GABA(A) RECEPTORS ; FRONTAL-CORTEX ; RIGHTING REFLEX ; NMDA RECEPTOR ; BETEL-QUID ; IN-VIVO ; ALCOHOL
英文摘要

Background: Epidemiological evidence of co-use of alcohol and areca nuts suggests a potential central interaction between arecoline, a major alkaloid of areca and a muscarinic receptor agonist, and ethanol. Moreover, the central cholinergic system plays an important role in the depressant action of ethanol and barbiturates. The purpose of this study was to investigate the effects of arecoline on pentobarbital- and ethanol-induced hypnosis in mice.

Methods: Male ICR mice were tested for locomotor activity following acute systemic administration of ethanol alone, arecoline alone. or ethanol Plus arccoline. For the loss of the righting reflex (LORR) induced by pentobarbital and ethanol, sleep latency and sleeping duration were evaluated in mice treated with arecoline alone or the combination of arecoline and scopolamine or methscopolamine.

Results: Ethanol (1.0 to 3.0 g/kg, i.p.) reduced locoinotor activity significantly and a declining trend was observed after treatment with arecoline (0.25 to 1.0 mg/kg, i.p.), but there were no synergistic effects of ethanol and arecoline on locomotor activity. The experiments on LORR demonstrated that arecoline (0.125 to 1.0 mg/kg, s.c.) shortened the duration of sleeping induced by ethanol (4.0 g/k, i.p.), but not pentobarbital (45 mg/k, i.p.). In addition, alterations of sleep latency were not obvious in both pentobarbital- and ethanol-induced LORR. Statistical analyses revealed that scopolarnine (centrally acting), but not methscopolamine (peripherally acting), could antagonize the effect of arecoline on the duration of ethanol-induced LORR in mice.

Conclusions: These results Suggest that central muscarinic receptor is a pharmacological target for the action of arecoline to Modulate ethanol-induced hypnosis.

语种英语
WOS记录号WOS:000273391700018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66364
专题中国药物依赖性研究所
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.RMIT Univ, Cardiovasc Neurosci & Neuropharmacol Res Grp, Sch Med Sci, Melbourne, Vic, Australia
3.Univ Melbourne, Howard Florey Inst & Ctr Neurosci, Melbourne, Vic 3010, Australia
推荐引用方式
GB/T 7714
Sun, Yan-Ping,Liu, Qing,Luo, Juan,et al. Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH,2010,34(1):150-157.
APA Sun, Yan-Ping.,Liu, Qing.,Luo, Juan.,Guo, Ping.,Chen, Feng.,...&Liang, Jian-Hui.(2010).Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice.ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH,34(1),150-157.
MLA Sun, Yan-Ping,et al."Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice".ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 34.1(2010):150-157.
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