北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice
作者: Sun, Yan-Ping; Liu, Qing; Luo, Juan; Guo, Ping; Chen, Feng2; Lawrence, Andrew J.3; Liang, Jian-Hui1
关键词: Ethanol ; Pentobarbital ; Arecoline ; Muscarinic Receptor ; Loss of the Righting Reflex
刊名: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
发表日期: 2010
DOI: 10.1111/j.1530-0277.2009.01076.x
卷: 34, 期:1, 页:150-157
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse
研究领域[WOS]: Substance Abuse
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; FREELY MOVING RATS ; ACETYLCHOLINE-RELEASE ; GABA(A) RECEPTORS ; FRONTAL-CORTEX ; RIGHTING REFLEX ; NMDA RECEPTOR ; BETEL-QUID ; IN-VIVO ; ALCOHOL
英文摘要:

Background: Epidemiological evidence of co-use of alcohol and areca nuts suggests a potential central interaction between arecoline, a major alkaloid of areca and a muscarinic receptor agonist, and ethanol. Moreover, the central cholinergic system plays an important role in the depressant action of ethanol and barbiturates. The purpose of this study was to investigate the effects of arecoline on pentobarbital- and ethanol-induced hypnosis in mice.

Methods: Male ICR mice were tested for locomotor activity following acute systemic administration of ethanol alone, arecoline alone. or ethanol Plus arccoline. For the loss of the righting reflex (LORR) induced by pentobarbital and ethanol, sleep latency and sleeping duration were evaluated in mice treated with arecoline alone or the combination of arecoline and scopolamine or methscopolamine.

Results: Ethanol (1.0 to 3.0 g/kg, i.p.) reduced locoinotor activity significantly and a declining trend was observed after treatment with arecoline (0.25 to 1.0 mg/kg, i.p.), but there were no synergistic effects of ethanol and arecoline on locomotor activity. The experiments on LORR demonstrated that arecoline (0.125 to 1.0 mg/kg, s.c.) shortened the duration of sleeping induced by ethanol (4.0 g/k, i.p.), but not pentobarbital (45 mg/k, i.p.). In addition, alterations of sleep latency were not obvious in both pentobarbital- and ethanol-induced LORR. Statistical analyses revealed that scopolarnine (centrally acting), but not methscopolamine (peripherally acting), could antagonize the effect of arecoline on the duration of ethanol-induced LORR in mice.

Conclusions: These results Suggest that central muscarinic receptor is a pharmacological target for the action of arecoline to Modulate ethanol-induced hypnosis.

语种: 英语
WOS记录号: WOS:000273391700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66364
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.RMIT Univ, Cardiovasc Neurosci & Neuropharmacol Res Grp, Sch Med Sci, Melbourne, Vic, Australia
3.Univ Melbourne, Howard Florey Inst & Ctr Neurosci, Melbourne, Vic 3010, Australia

Recommended Citation:
Sun, Yan-Ping,Liu, Qing,Luo, Juan,et al. Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH,2010,34(1):150-157.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Yan-Ping]'s Articles
[Liu, Qing]'s Articles
[Luo, Juan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Yan-Ping]‘s Articles
[Liu, Qing]‘s Articles
[Luo, Juan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace