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学科主题: 临床医学
题名:
Phenotypic and Genotypic Characteristic of Invasive Pneumococcal Isolates from Both Children and Adult Patients from a Multicenter Surveillance in China 2005-2011
作者: Zhao, Chunjiang1; Zhang, Feifei1; Chu, Yunzhuo2; Liu, Yong3; Cao, Bin4; Chen, Minjun5; Yu, Yunsong6; Liao, Kang7; Zhang, Liyan8; Sun, Ziyong9; Hu, Bijie10; Lei, Jin′ e(11); Hu, Zhidong12; Zhang, Xiaobing13; Wang, Hui1
刊名: PLOS ONE
发表日期: 2013-12-11
DOI: 10.1371/journal.pone.0082361
卷: 8, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PNEUMONIAE SEROTYPE 19A ; STREPTOCOCCUS-PNEUMONIAE ; CONJUGATE VACCINE ; ANTIMICROBIAL RESISTANCE ; ANTIBIOTIC-RESISTANCE ; UNITED-STATES ; DISEASE ; EPIDEMIOLOGY ; IMPACT ; RISK
英文摘要:

Streptococcus pneumoniae is an important pathogen in both children and the elderly, but previous studies in China have provided limited information about invasive pneumococcal disease (IPD). A total of 240 IPD S. pneumoniae strains (from 105 children and 135 adults) were collected from 12 cities in China in 2005-2011. Their phenotypes and genetic characteristics were analyzed. Streptococcus pneumoniae remained highly resistant to macrolides, tetracycline, and cotrimoxazole each year. Serotypes were assigned to the 240 isolates, and 19A (22.1%), 19F (21.7%), 14 (7.5%), 3 (7.1%), and 23F (5.4%) were the most prevalent, accounting for 63.8% of all strains. Serogroup 19 strains were significantly more common among children than among adults (58.7% vs 32.4%, respectively; P < 0.001). Serotypes 19F and 19A demonstrated higher resistance to beta-lactams and cephalosporins than the other serotypes. The coverage of PCV13 was superior to that calculated for PCV7 and PCV10 (77.9% vs 40.8% and 47.1%, respectively), and coverage was higher in children than in adults (85.6% vs 72.1%, respectively; P = 0.012). A multilocus sequence typing analysis revealed great diversity, with nine clonal complexes and 83 singletons among all the strains. Specifically, CC271 was more common in children, whereas singletons were more prevalent in adults. Among the serogroup 19 strains, 84.7% were ST271, ST320, or ST236, belonging to CC271. The homogeneous genetic background of 19F and 19A, together with the high resistance of these strains, suggests that clonal spread is responsible for the high prevalence of serogroup 19 in IPD. This is the first large study to investigate IPD strains in both children and adults in China.

语种: 英语
项目资助者: GPRS project of Sanofi-Aventis, Pharmaceuticals Co., Ltd.
WOS记录号: WOS:000328730300089
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66366
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100871, Peoples R China
3.China Med Univ, Hosp 1, Dept Clin Lab, Shenyang, Liaoning, Peoples R China
4.China Med Univ, Shengjing Hosp, Dept Clin Lab, Shenyang, Liaoning, Peoples R China
5.Capital Med Univ, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
6.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China
7.Hangzhou Univ, Sch Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510275, Guangdong, Peoples R China
9.Guangdong Gen Hosp, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China
10.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China
11.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Clin Lab, Xian 710049, Shaanxi, Peoples R China
12.Tianjin Med Univ, Gen Hosp, Dept Clin Lab, Tianjin, Peoples R China
13.Southwest Hosp, Dept Clin Lab, Chongqing, Peoples R China

Recommended Citation:
Zhao, Chunjiang,Zhang, Feifei,Chu, Yunzhuo,et al. Phenotypic and Genotypic Characteristic of Invasive Pneumococcal Isolates from Both Children and Adult Patients from a Multicenter Surveillance in China 2005-2011[J]. PLOS ONE,2013,8(12).
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