IR@PKUHSC  > 北京大学第三临床医学院  > 普通外科
学科主题临床医学
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
Gao, Chan1,2; Cao, Weipeng1,2; Bao, Lan3; Zuo, Wei1,2; Xie, Guoming1,2; Cai, Tiantian2; Fu, Wei4; Zhang, Jian5; Wu, Wei2; Zhang, Xu3; Chen, Ye-Guang1,2
刊名NATURE CELL BIOLOGY
2010-08-01
DOI10.1038/ncb2082
12期:8页:781-U38
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Natural Science Foundation of China ; 973 Program ; National Natural Science Foundation of China ; 973 Program
研究领域[WOS]Cell Biology
关键词[WOS]LINDAU TUMOR-SUPPRESSOR ; REQUIRES DIRECT BINDING ; SELECTIVE AUTOPHAGY ; MAMMALIAN-CELLS ; CATENIN PATHWAY ; BETA-CATENIN ; PROTEIN ; UBIQUITINATION ; GENE ; DISEASE
英文摘要

In eukaryotic cells, autophagy is a highly conserved self-digestion process to promote cell survival in response to nutrient starvation and other metabolic stresses. Autophagy is regulated by cell signalling such as the mTOR (mammalian target of rapamycin) pathway. However, the significance of autophagy in modulation of signal transduction is unclear. Here we show that autophagy negatively regulates Wnt signalling by promoting Dishevelled (Dvl) degradation. Von Hippel-Lindau protein-mediated ubiquitylation is critical for the binding of Dvl2 to p62, which in turn facilitates the aggregation and the LC3-mediated autophagosome recruitment of Dvl2 under starvation; the ubiquitylated Dvl2 aggregates are ultimately degraded through the autophagy-lysosome pathway. Moreover, a reverse correlation between Dvl expression and autophagy is observed in late stages of colon cancer development, indicating that autophagy may contribute to the aberrant activation of Wnt signalling in tumour formation.

语种英语
所属项目编号30930050 ; 30921004 ; 2006CB943401 ; 2010CB833706
资助者National Natural Science Foundation of China ; 973 Program ; National Natural Science Foundation of China ; 973 Program
WOS记录号WOS:000280561600010
引用统计
被引频次:164[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66371
专题北京大学第三临床医学院_普通外科
作者单位1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
5.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Gao, Chan,Cao, Weipeng,Bao, Lan,et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation[J]. NATURE CELL BIOLOGY,2010,12(8):781-U38.
APA Gao, Chan.,Cao, Weipeng.,Bao, Lan.,Zuo, Wei.,Xie, Guoming.,...&Chen, Ye-Guang.(2010).Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.NATURE CELL BIOLOGY,12(8),781-U38.
MLA Gao, Chan,et al."Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation".NATURE CELL BIOLOGY 12.8(2010):781-U38.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Chan]的文章
[Cao, Weipeng]的文章
[Bao, Lan]的文章
百度学术
百度学术中相似的文章
[Gao, Chan]的文章
[Cao, Weipeng]的文章
[Bao, Lan]的文章
必应学术
必应学术中相似的文章
[Gao, Chan]的文章
[Cao, Weipeng]的文章
[Bao, Lan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。