IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo
Wang, Jian; Murata, Satoru; Kumazaki, Tatsuo
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2006-07-14
12期:26页:4214-4218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; IODIZED OIL ; LIPIODOL ; CHEMOEMBOLIZATION ; INJECTION ; RAT
英文摘要

AIM: To observe the dynamic changes of liver microcirculation in vivo after arterial embolization with degradable starch microspheres (DSM).

METHODS: DSM were injected into the proper hepatic artery through a silastic tube inserted retrogradely in gastrocluodenal artery (GDA) of SD rats. Fluorescent microscopy was used to evaluate the dynamic changes of blood flow through the terminal portal venules (TPVs), sinusoids and terminal hepatic venules (THVs). The movements of DSM debris were also recorded. Six hours after injection of DSM, percentages of THVs with completely stagnant blood flow were recorded.

RESULTS: Two phases of blood flow change were recorded. In phase one: after intra-arterial injection of DSM, slow or stagnant blood flow was immediately recorded in TPVs, sinusoids and THVs. This change was reversible, and blood flow resumed completely. In phase two: after phase one, blood flow in TPVs changed again and three patterns of blood flow were recorded. Six hours after DSM injection, 36.9% 9.2% of THVs were found with completely stagnant blood flow.

CONCLUSION: DSM can stop the microcirculatory blood flow in some areas of liver parenchyma. Liver parenchyma supplied by arteries with larger A-P shunt is considered at a higher risk of total microcirculatory blood stagnation after injection of DSM through hepatic artery. (c) 2006 The WIG Press. All rights reserved.

语种英语
WOS记录号WOS:000239997800020
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66379
专题北京大学第一临床医学院
作者单位1.Nippon Med Coll, Dept Radiol, Tokyo 113, Japan
2.Peking Univ, Hosp 1, Dept Intervent Radiol & Vasc Surg, Beijing 100034, Peoples R China
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GB/T 7714
Wang, Jian,Murata, Satoru,Kumazaki, Tatsuo. Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12(26):4214-4218.
APA Wang, Jian,Murata, Satoru,&Kumazaki, Tatsuo.(2006).Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo.WORLD JOURNAL OF GASTROENTEROLOGY,12(26),4214-4218.
MLA Wang, Jian,et al."Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo".WORLD JOURNAL OF GASTROENTEROLOGY 12.26(2006):4214-4218.
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