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Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy
Liu, Z.1; Zheng, D.2; Wang, X.1; Zhang, J.2,3; Xie, S.1; Xiao, J.1; Jiang, X.1
刊名AMERICAN JOURNAL OF NEURORADIOLOGY
2011-05-01
DOI10.3174/ajnr.A2395
32期:5页:898-902
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]STROKE-LIKE EPISODES ; MAGNETIC-RESONANCE-SPECTROSCOPY ; RAT-BRAIN ; IN-VIVO ; MITOCHONDRIAL ENCEPHALOMYOPATHY ; VASCULAR INVOLVEMENT ; N-ACETYLASPARTATE ; CEREBRAL-ISCHEMIA ; LACTIC-ACIDOSIS ; MUTATION
英文摘要

BACKGROUND AND PURPOSE: DW-MR spectroscopy can detect the diffusion coefficients of NAA, Cr, PCr, and Cho and can, therefore, provide some useful information. The aims of this study were to probe the mechanisms underlying the pathogenesis of MELAS and to see whether DW-MR spectroscopy is a useful technique for other diseases besides cerebral infarction.

MATERIALS AND METHODS: Fifteen healthy volunteers and 10 patients with MELAS were enrolled in the study. All were scanned on a 3T whole-body MR imaging scanner. Fifteen ADCs of the singlet metabolites in the gray matter of the healthy subjects, 10 ADCs of the singlet metabolites in the lesions, and 8 ADCs of the singlet metabolites in the nonaffected areas were used in the statistical analysis, respectively.

RESULTS: The metabolite ADCs of the nonaffected areas and the lesions in the patients were higher than those of the frontal gray matter in the healthy controls. There were significant differences between the metabolite ADCs of the nonaffected areas in patients and those in the healthy controls, and it was the same with the metabolite ADCs of the lesions and those of the healthy controls.

CONCLUSIONS: The increased ADC values of the metabolites reveal that MELAS is a mitochondrial neuronopathy and involves the entire brain. DW-MR spectroscopy is a very useful noninvasive technique, which can show some valuable information that conventional MR imaging cannot display. Thus, it can be applied to brain diseases besides cerebral infarction.

语种英语
WOS记录号WOS:000291117600020
资助机构Fundamental Research Funds for the Central Universities ; Ministry of Education of the People&prime ; s Republic of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66387
专题北京大学第一临床医学院_放射治疗科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 1, Dept Radiol, Ctr Funct Imaging, Beijing 100034, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100034, Peoples R China
3.Peking Univ, Dept Coll Engn, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Liu, Z.,Zheng, D.,Wang, X.,et al. Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2011,32(5):898-902.
APA Liu, Z..,Zheng, D..,Wang, X..,Zhang, J..,Xie, S..,...&Jiang, X..(2011).Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy.AMERICAN JOURNAL OF NEURORADIOLOGY,32(5),898-902.
MLA Liu, Z.,et al."Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy".AMERICAN JOURNAL OF NEURORADIOLOGY 32.5(2011):898-902.
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