北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科  > 期刊论文
学科主题: 临床医学
题名:
Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy
作者: Liu, Z.1; Zheng, D.2; Wang, X.1; Zhang, J.2,3; Xie, S.1; Xiao, J.1; Jiang, X.1
刊名: AMERICAN JOURNAL OF NEURORADIOLOGY
发表日期: 2011-05-01
DOI: 10.3174/ajnr.A2395
卷: 32, 期:5, 页:898-902
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: STROKE-LIKE EPISODES ; MAGNETIC-RESONANCE-SPECTROSCOPY ; RAT-BRAIN ; IN-VIVO ; MITOCHONDRIAL ENCEPHALOMYOPATHY ; VASCULAR INVOLVEMENT ; N-ACETYLASPARTATE ; CEREBRAL-ISCHEMIA ; LACTIC-ACIDOSIS ; MUTATION
英文摘要:

BACKGROUND AND PURPOSE: DW-MR spectroscopy can detect the diffusion coefficients of NAA, Cr, PCr, and Cho and can, therefore, provide some useful information. The aims of this study were to probe the mechanisms underlying the pathogenesis of MELAS and to see whether DW-MR spectroscopy is a useful technique for other diseases besides cerebral infarction.

MATERIALS AND METHODS: Fifteen healthy volunteers and 10 patients with MELAS were enrolled in the study. All were scanned on a 3T whole-body MR imaging scanner. Fifteen ADCs of the singlet metabolites in the gray matter of the healthy subjects, 10 ADCs of the singlet metabolites in the lesions, and 8 ADCs of the singlet metabolites in the nonaffected areas were used in the statistical analysis, respectively.

RESULTS: The metabolite ADCs of the nonaffected areas and the lesions in the patients were higher than those of the frontal gray matter in the healthy controls. There were significant differences between the metabolite ADCs of the nonaffected areas in patients and those in the healthy controls, and it was the same with the metabolite ADCs of the lesions and those of the healthy controls.

CONCLUSIONS: The increased ADC values of the metabolites reveal that MELAS is a mitochondrial neuronopathy and involves the entire brain. DW-MR spectroscopy is a very useful noninvasive technique, which can show some valuable information that conventional MR imaging cannot display. Thus, it can be applied to brain diseases besides cerebral infarction.

语种: 英语
项目资助者: Fundamental Research Funds for the Central Universities ; Ministry of Education of the People&prime ; s Republic of China
WOS记录号: WOS:000291117600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66387
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Ctr Funct Imaging, Beijing 100034, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100034, Peoples R China
3.Peking Univ, Dept Coll Engn, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Z.,Zheng, D.,Wang, X.,et al. Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2011,32(5):898-902.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Z.]'s Articles
[Zheng, D.]'s Articles
[Wang, X.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Z.]‘s Articles
[Zheng, D.]‘s Articles
[Wang, X.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace