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学科主题: 临床医学
题名:
TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection
作者: Wang, Jiang-Xue1; Fan, Yu-Bo1; Gao, Yu1; Hu, Qing-Hua1; Wang, Tian-Cheng2
关键词: Nanoparticles ; TiO2 biomaterials ; Intraarticular injection ; Toxicological effect ; Oxidative stress
刊名: BIOMATERIALS
发表日期: 2009-09-01
DOI: 10.1016/j.biomaterials.2009.05.008
卷: 30, 期:27, 页:4590-4600
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: IN-VIVO ; WEAR PARTICLES ; ULTRAFINE PARTICLES ; LUNG INJURY ; CELL-LINE ; TITANIUM ; BIOMATERIALS ; INDUCTION ; DEBRIS ; VITRO
英文摘要:

Recently, nanomaterials coating gained much concern in orthopedic implants such as bone, cartilage, joint, etc. The wear particles would generate from coating in living organism due to corrosion. In this study, we demonstrated that the intraarticular injected anatase TiO2 nanoparticles had a potential toxicological effect on major organs and knee joints of rats. The histopathological changes of heart, lung and liver indicated the dissemination of intraarticular TiO2 nanoparticles from joint cavity to system. In the knee joint, the aggregated TiO2 nanoparticles deposited and resulted in the synovium hypotrophy and lymphocytes and plasma cells infiltration, but had no effects on cartilage. In the TiO2-exposed synovium, the oxidative damage was induced because the glutathione peroxidase (GSH-Px), reduced glutathione (GSH), oxidized glutathione (GSSG), and superoxide dismutase (SOD) levels were highly regulated to counteract over-produced free radicals, i.e. hydrogen peroxide (H2O2). Further, the lipid peroxidation was detected in the synovium though the expression of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL-1 beta) was not much interfered. This research suggested that the amounts of nanocoating in the surface of implants should be controlled and standardized. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30800217 ; 10672015 ; 20080430304
项目资助者: National Natural Science Foundation of China ; Postdoctoral Science Foundation of China
WOS记录号: WOS:000269330400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66388
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
2.Peking Univ, Dept Clin Lab Med, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Jiang-Xue,Fan, Yu-Bo,Gao, Yu,et al. TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection[J]. BIOMATERIALS,2009,30(27):4590-4600.
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