北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study
作者: Shi, Xiaoli1; Qin, Lei2; Zhang, Xuejie1; He, Kangmin1,3; Xiong, Chunyang3; Fang, Jing3; Fang, Xiaohong1; Zhang, Youyi2
刊名: PHYSICAL CHEMISTRY CHEMICAL PHYSICS
发表日期: 2011
DOI: 10.1039/c1cp20154a
卷: 13, 期:16, 页:7540-7545
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]: Chemistry ; Physics
关键词[WOS]: LIVING CELLS ; CYTOSKELETAL STRUCTURE ; FIBROBLASTS ; HEART ; LOCOMOTION ; MECHANICS ; RIGIDITY ; ADHESION
英文摘要:

Influences of substrate stiffness on mechanical properties of cardiac myocytes and fibroblasts were investigated by cell elasticity measurement with atomic force microscopy. The cells were cultured on collagen-coated polyacrylamide substrates with gradient rigidity. While cardiac myocytes showed no evident change in cell elasticity on different substrates, cardiac fibroblasts displayed the non-monotonic dependence on substrate stiffness with a maximum elastic modulus. Moreover, the elasticity change of cardiac fibroblasts with substrates stiffness was found to be regulated by actin filaments. Study of the effect of substrate stiffness on cell elasticity for different cardiac cells provides new information for the better understanding of cardiac physiology and pathology.

语种: 英语
所属项目编号: 2007CB935601 ; 30821001 ; 81030001
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000289203800033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66389
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China
2.Peking Univ, Inst Vasc Med, Hosp 3, Minist Educ Key Lab Mol, Beijing 100191, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China

Recommended Citation:
Shi, Xiaoli,Qin, Lei,Zhang, Xuejie,et al. Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2011,13(16):7540-7545.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Xiaoli]'s Articles
[Qin, Lei]'s Articles
[Zhang, Xuejie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Xiaoli]‘s Articles
[Qin, Lei]‘s Articles
[Zhang, Xuejie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace