IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study
Shi, Xiaoli1; Qin, Lei2; Zhang, Xuejie1; He, Kangmin1,3; Xiong, Chunyang3; Fang, Jing3; Fang, Xiaohong1; Zhang, Youyi2
刊名PHYSICAL CHEMISTRY CHEMICAL PHYSICS
2011
DOI10.1039/c1cp20154a
13期:16页:7540-7545
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]Chemistry ; Physics
关键词[WOS]LIVING CELLS ; CYTOSKELETAL STRUCTURE ; FIBROBLASTS ; HEART ; LOCOMOTION ; MECHANICS ; RIGIDITY ; ADHESION
英文摘要

Influences of substrate stiffness on mechanical properties of cardiac myocytes and fibroblasts were investigated by cell elasticity measurement with atomic force microscopy. The cells were cultured on collagen-coated polyacrylamide substrates with gradient rigidity. While cardiac myocytes showed no evident change in cell elasticity on different substrates, cardiac fibroblasts displayed the non-monotonic dependence on substrate stiffness with a maximum elastic modulus. Moreover, the elasticity change of cardiac fibroblasts with substrates stiffness was found to be regulated by actin filaments. Study of the effect of substrate stiffness on cell elasticity for different cardiac cells provides new information for the better understanding of cardiac physiology and pathology.

语种英语
WOS记录号WOS:000289203800033
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66389
专题北京大学第三临床医学院_心血管内科
作者单位1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China
2.Peking Univ, Inst Vasc Med, Hosp 3, Minist Educ Key Lab Mol, Beijing 100191, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Shi, Xiaoli,Qin, Lei,Zhang, Xuejie,et al. Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2011,13(16):7540-7545.
APA Shi, Xiaoli.,Qin, Lei.,Zhang, Xuejie.,He, Kangmin.,Xiong, Chunyang.,...&Zhang, Youyi.(2011).Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,13(16),7540-7545.
MLA Shi, Xiaoli,et al."Elasticity of cardiac cells on the polymer substrates with different stiffness: an atomic force microscopy study".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 13.16(2011):7540-7545.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Xiaoli]的文章
[Qin, Lei]的文章
[Zhang, Xuejie]的文章
百度学术
百度学术中相似的文章
[Shi, Xiaoli]的文章
[Qin, Lei]的文章
[Zhang, Xuejie]的文章
必应学术
必应学术中相似的文章
[Shi, Xiaoli]的文章
[Qin, Lei]的文章
[Zhang, Xuejie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。